Evidence map›Paper›PMID 31771992›Full record

ArticleDisease models & mechanisms2019

Impaired neural differentiation and glymphatic CSF flow in the

A Scott Emmert, Eri Iwasawa, Crystal Shula, Preston Schultz, Diana Lindquist, R Scott Dunn, Elizabeth M Fugate, Yueh-Chiang Hu, Francesco T Mangano, June Goto

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Development of perivascular astrocyte processes.Frontiers in neuroscience · 2025
    Review
  3. The Glymphatic System and Its Role in Neurovascular Diseases.Journal of neuroendovascular therapy · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Fluid transport in the brain.Physiological reviews · 2022
    Review
  8. Article
  9. Ependymal Cilia: Physiology and Role in Hydrocephalus.Frontiers in molecular neuroscience · 2022
    Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

A Scott EmmertDivision of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Eri IwasawaDivision of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Crystal ShulaDivision of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Preston SchultzDivision of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Diana LindquistDivision of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
R Scott DunnDivision of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.ORCID 0000-0001-8501-8290
Elizabeth M FugateDivision of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Yueh-Chiang HuDevelopmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Francesco T ManganoDivision of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
June GotoDivision of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA june.goto@cchmc.org.ORCID 0000-0002-4000-9750
Cincinnati Children's Hospital Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonatal hydrocephalus affects about one child per 1000 births and is a major congenital brain abnormality. We previously discovered a gene mutation within the coiled-coil domain-containing 39 (

Indexed as

Disease Models, AnimalMutationAnimalsAnimals, NewbornCell DeathCell DifferentiationCerebrospinal FluidCRISPR-Cas SystemsCytoskeletal ProteinsGlymphatic SystemHydrocephalusNeural Cell Adhesion Molecule L1NeuronsRatsRats, Sprague-DawleyCCDC39 protein, humanCytoskeletal ProteinsNeural Cell Adhesion Molecule L1CRISPR-CasGenetic modelGlymphaticNeocorticogenesisNeonatal hydrocephalusRat model

Identifiers

PMID31771992
PMCPMC6898999
OpenAlexW2991614933

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.