ArticleParticle and fibre toxicology2019
Selective memory and behavioral alterations after ambient ultrafine particulate matter exposure in aged 3xTgAD Alzheimer's disease mice.
Article in Particle and fibre toxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Air quality and health implications of exposure to ultrafine particle pollution.Cardiovascular research · 2026Article
- Comparing effects of gaseous vs. particulate components of traffic-related air pollution on Alzheimer's disease biomarkers in a genetically susceptible rat model.Neurotoxicology · 2026Article
- Traffic-Related Emissions Induce Angiotensin II-Dependent Oxidative Stress in the Hippocampus of ApoE-Null Male Mice.Antioxidants (Basel, Switzerland) · 2026Article
- Varenicline Attenuates Memory Impairment in Amyloid-Beta-Induced Rat Model of Alzheimer's Disease.Neurochemical research · 2025Article
- Spatiotemporal Mapping of Ultrafine Particle Fluxes in an Office HVAC System with a Diffusion Charger Sensor Array.ACS ES&T air · 2025Article
- Air Pollution as an Environmental Risk Factor for Alzheimer's Disease and Related Dementias.Medical research archives · 2024Article
- Investigating the Potential Impact of Air Pollution on Alzheimer's Disease and the Utility of Multidimensional Imaging for Early Detection.ACS omega · 2024Review
- Effective density of inhaled environmental and engineered nanoparticles and its impact on the lung deposition and dosimetry.Particle and fibre toxicology · 2024Article
- Deciphering the Influence of Estradiol and Estrogen Receptors on Cognitive Function: A Bibliometric Analysis and Emerging Research Trends.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Exposure to quasi-ultrafine particulate matter accelerates memory impairment and Alzheimer's disease-like neuropathology in the AppNL-G-F knock-in mouse model.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- The bidirectional lung brain-axis of amyloid-β pathology: ozone dysregulates the peri-plaque microenvironment.Brain : a journal of neurology · 2023Article
- Evaluation of the Effect of Air Pollution on Cognitive Functions, Cognitive Decline, and Dementia.Annals of Indian Academy of Neurology · 2022Article
- Particulate matter and Alzheimer's disease: an intimate connection.Trends in molecular medicine · 2022Review
- White matter pathology in alzheimer's transgenic mice with chronic exposure to low-level ambient fine particulate matter.Particle and fibre toxicology · 2022Article
- The pathogenic effects of particulate matter on neurodegeneration: a review.Journal of biomedical science · 2022Review
- Effects of concentrated ambient ultrafine particulate matter on hallmarks of Alzheimer's disease in the 3xTgAD mouse model.Neurotoxicology · 2021Article
- The Effects of Chronic Exposure to Ambient Traffic-Related Air Pollution on Alzheimer's Disease Phenotypes in Wildtype and Genetically Predisposed Male and Female Rats.Environmental health perspectives · 2021Article
- Particulate Matter and Associated Metals: A Link with Neurotoxicity and Mental Health.Atmosphere · 2021Article
- Three month inhalation exposure to low-level PM2.5 induced brain toxicity in an Alzheimer's disease mouse model.PloS one · 2021Article
- Brain correlates of urban environmental exposures in cognitively unimpaired individuals at increased risk for Alzheimer's disease: A study on Barcelona's population.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundA growing body of epidemiological literature indicates that particulate matter (PM) air pollution exposure is associated with elevated Alzheimer's disease (AD) risk and may exacerbate AD-related cognitive decline. Of concern is exposure to the ultrafine PM (UFP) fraction (≤100 nm), which deposits efficiently throughout the respiratory tract, has higher rates of translocation to secondary organs, like brain, and may induce inflammatory changes. We, therefore, hypothesize that exposure to UFPs will exacerbate cognitive deficits in a mouse model of AD. The present study assessed alterations in learning and memory behaviors in aged (12.5 months) male 3xTgAD and non-transgenic mice following a 2-week exposure (4-h/day, 4 days/week) to concentrated ambient UFPs using the Harvard ultrafine concentrated ambient particle system (HUCAPS) or filtered air. Beginning one month following exposure, locomotor activity, spatial learning and memory, short-term recognition memory, appetitive motivation, and olfactory discrimination were assessed.
resultsNo effects on locomotor activity were found following HUCAPS exposure (number concentration, 1 × 10
conclusionsA short-term inhalation exposure of aged mice to ambient UFPs at human-relevant concentrations resulted in protracted (testing spanning 1-6.5 months post-exposure) adverse effects on multiple memory domains (reference and short-term memory) independent of AD background. Impairments in learning and memory were present when accounting for potential covariates like motivational changes and locomotor activity. These results highlight the need for further research into the potential mechanisms underlying the cognitive effects of UFP exposure in adulthood.
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