Evidence map›Paper›PMID 31771473›Full record

ArticleProceedings. Biological sciences2019

An X-linked meiotic drive allele has strong, recessive fitness costs in female

William Larner, Tom Price, Luke Holman, Nina Wedell

Abstract read
In one paragraph

Article in Proceedings. Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. The metabolic costs of meiotic drive.Proceedings. Biological sciences · 2025
    Article
  3. A selfish supergene causes meiotic drive through both sexes inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. Sexual selection can partly explain low frequencies ofProceedings. Biological sciences · 2021
    Article
  7. Article
  8. Article
  9. Resistance to natural and synthetic gene drive systems.Journal of evolutionary biology · 2020
    Review
  10. Article
  11. Ancient gene drives: an evolutionary paradox.Proceedings. Biological sciences · 2019
    Article
  12. Gene drive: progress and prospects.Proceedings. Biological sciences · 2019
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

William LarnerBiosciences, University of Exeter, Penryn Campus, Penryn TR10 9FE, UK.
Tom PriceInstitute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK.
Luke HolmanSchool of Biosciences, University of Melbourne, Parkville, Victoria 3010, Australia.
Nina WedellBiosciences, University of Exeter, Penryn Campus, Penryn TR10 9FE, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selfish 'meiotic drive' alleles are transmitted to more than 50% of offspring, allowing them to rapidly invade populations even if they reduce the fitness of individuals carrying them. Theory predicts that drivers should either fix or go extinct, yet some drivers defy these predictions by persisting at low, stable frequencies for decades. One possible explanation for this discrepancy is that drivers are especially costly when homozygous, although empirical tests of this idea are rare and equivocal. Here, we measure the fitness of female

Indexed as

Genetic FitnessMeiosisAnimalsDrosophilaFemaleGenes, InsectGenes, X-LinkedMaleNorth AmericaSex Rationegative frequency dependenceoffspring productionpolyandryselfish genetic elementssperm competition

Identifiers

PMID31771473
PMCPMC6939274

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.