ArticleProceedings. Biological sciences2019
The complex evolutionary history of sulfoxide synthase in ovothiol biosynthesis.
Article in Proceedings. Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- A compendium of horizontal gene transfers in Metazoa.Scientific data · 2026Article
- The eukaryotic horizontal gene transfer dataset a compendium.bioRxiv : the preprint server for biology · 2025Article
- Characterizing the Ultraviolet (UV) Screening Ability of L-5-Sulfanylhistidine Derivatives on Human Dermal Fibroblasts.Marine drugs · 2025Article
- Insights on the UV-Screening Potential of Marine-Inspired Thiol Compounds.Marine drugs · 2023Article
- Taxonomic Distribution and Molecular Evolution of Mytilectins.Marine drugs · 2023Review
- Glutathione Depletion Disrupts Redox Homeostasis in an Anoxia-Tolerant Invertebrate.Antioxidants (Basel, Switzerland) · 2023Article
- The Transcriptional Repressor PerR Senses Sulfane Sulfur by Cysteine Persulfidation at the Structural ZnAntioxidants (Basel, Switzerland) · 2023Article
- The first genetic engineered system for ovothiol biosynthesis in diatoms reveals a mitochondrial localization for the sulfoxide synthase OvoA.Open biology · 2023Article
- Ergothioneine, Ovothiol A, and Selenoneine-Histidine-Derived, Biologically Significant, Trace Global Alkaloids.Molecules (Basel, Switzerland) · 2022Review
- A Survey on the Distribution of Ovothiol andMarine drugs · 2022Article
- Ovothiol ensures the correct developmental programme of the sea urchinOpen biology · 2022Article
- First Report of OvoA Gene in Marine Arthropods: A New Candidate Stress Biomarker in Copepods.Marine drugs · 2021Article
- Metabolic Adaptations to Marine Environments: Molecular Diversity and Evolution of Ovothiol Biosynthesis in Bacteria.Genome biology and evolution · 2021Article
- From Sea to Skin: Is There a Future for Natural Photoprotectants?Marine drugs · 2021Review
- Small-molecule mimicry hunting strategy in the imperial cone snail,Science advances · 2021Article
- Insights into the Light Response ofMarine drugs · 2020Article
- Histochemical detection of free thiols in glandular cells and tissues of different marine Polychaeta.Histochemistry and cell biology · 2020Article
- New Cytotoxic Cerebrosides from the Red Sea CucumberMarine drugs · 2020Article
- Gametogenesis-Related Fluctuations in Ovothiol Levels in the Mantle of Mussels from Different Estuaries: Fighting Oxidative Stress for Spawning in Polluted Waters.Biomolecules · 2020Article
- Probing the Interactions of Sulfur-Containing Histidine Compounds with Human Gamma-Glutamyl Transpeptidase.Marine drugs · 2019Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sulfoxide synthases are enzymes involved in the biosynthesis of small sulfur-containing natural products. Their enzymatic activity represents a unique sulfur transfer strategy in nature that is the insertion of a sulfur atom on the imidazole ring of histidine. To date, only two enzymes are known to carry out this function: the sulfoxide synthase EgtB, involved in the biosynthesis of ergothioneine in fungi and bacteria, and the 5-histidylcysteine sulfoxide synthase OvoA, involved in the biosynthesis of ovothiols, found in the eggs and biological fluids of marine invertebrates, some proteobacteria and protists. In particular, ovothiols, thanks to their unique redox properties, are probably the most intriguing marine sulfur-containing molecules. Although they have long been considered as cellular protective molecules, new evidence suggest that their biological activities and ecological role might be more complex than originally thought. Here, we investigate the evolutionary history of OvoA in Metazoa, reporting its monophyletic ancient origins, which could be traced back to the latest common ancestor of Choanozoa. Nevertheless, we show that OvoA is missing in several major extant taxa and we discuss this patchy distribution in the light of the massive genome reduction events documented in Metazoa. We also highlight two interesting cases of secondary acquisition through horizontal gene transfer, which occurred in hydrozoans and bdelloid rotifers. The evolutionary success of this metabolic pathway is probably ascribable to its role in the maintenance of cellular redox homeostasis, which enables organisms to survive in different environmental niches.
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