SynthesisStroke2020
Blood Pressure Variability and Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis of Population-Based Cohorts.
Synthesis in Stroke, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
101 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Blood pressure variability predicts poor outcomes in acute stroke patients without thrombolysis: a systematic review and meta-analysis.Journal of neurology · 2024Pooled it
- Effect of leukoaraiosis on collateral circulation in acute ischemic stroke treated with endovascular therapy: a meta-analysis.BMC neurology · 2023Pooled it
- Effect of exercise training on blood pressure variability in adults: A systematic review and meta-analysis.PloS one · 2023Pooled it
- Association Between Blood Pressure Variability With Dementia and Cognitive Impairment: A Systematic Review and Meta-Analysis.Hypertension (Dallas, Tex. : 1979) · 2021Pooled it
- Prognostic Value of Blood Pressure Variability for Patients With Acute or Subacute Intracerebral Hemorrhage: A Meta-Analysis of Prospective Studies.Frontiers in neurology · 2021Pooled it
- Visit-to-Visit Blood Pressure Variability and Cerebral White Matter Lesion Progression: A Pooled Individual Patient Data Analysis of 2 Trials.Neurology · 2026Trial
- Comparison of visit-to-visit blood pressure variability and time in target range in predicting risk for cognitive outcomes in the SPRINT trial.Journal of Alzheimer's disease : JAD · 2025Trial
- Allopurinol and blood pressure variability following ischemic stroke and transient ischemic attack: a secondary analysis of XILO-FIST.Journal of human hypertension · 2024Trial
- 24-Hour Blood Pressure Variability Via Ambulatory Monitoring and Risk for Probable Dementia in the SPRINT Trial.The journal of prevention of Alzheimer's disease · 2024Trial
- Blood Pressure Variability and Cerebral Perfusion Decline: A Post Hoc Analysis of the SPRINT MIND Trial.Journal of the American Heart Association · 2023Trial
- Blood Pressure Variability and Cognitive Decline: A Post Hoc Analysis of the SPRINT MIND Trial.American journal of hypertension · 2023Trial
- Heart failure with preserved ejection fraction in women: a sex-specific clinical review.The Korean journal of internal medicine · 2026Review
- Blood pressure variability and frailty: mechanisms, evidence, and clinical implications.International urology and nephrology · 2026Review
- Prognostic enrichment or treatment-target modification? Interpreting MRI-defined asymptomatic brain lesions in blood-pressure research.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Cerebral small vessel disease: pearls and pitfalls from unexplored risk factors to treatment.Arquivos de neuro-psiquiatria · 2026Review
- Blood Pressure Variability is Associated With Lower Cognitive Function: An Elderly Cohort Study in Hong Kong.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Long-Term Blood Pressure Variability in Cerebral Amyloid Angiopathy is Associated with Ischemic Brain Injury and Cognitive Decline.Journal of the American Heart Association · 2026Observational
- Article
- Interactions between blood pressure variability, cerebral autoregulation, and covert cerebral small vessel disease in relation to cognitive performance in community-dwelling older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Visit-to-visit blood pressure variability, brain MRI measures, and cognition in non-demented older adults.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Background and Purpose- Blood pressure (BP) variability may increase the risk of stroke and dementia. It remains inconclusive whether BP variability is associated with cerebral small vessel disease, a common and potentially devastating subclinical disease that contributes significantly to both stroke and dementia. Methods- A systematic review and meta-analysis of prospective cohort studies that examined the association between BP variability and the presence or progression of established markers of cerebral small vessel disease, including white matter hyperintensities, lacunes, and microbleeds on magnetic resonance imaging. We searched MEDLINE, EMBASE, and Web of Science. Ten studies met the criteria for qualitative synthesis and 7 could be included in the meta-analysis. Data were synthetized using random-effect models. Results- These studies included a total of 2796 individuals aged 74 (mean) ±4 (SD) years, with a median follow-up of 4.0 years. A one SD increase in systolic BP variability was associated with increased odds of the presence or progression of white matter hyperintensities (odds ratio, 1.26 [95% CI, 1.06-1.50]). The association of systolic BP variability with the presence of lacunes (odds ratio, 0.93 [95% CI, 0.74-1.16]) and the presence of microbleeds (odds ratio, 1.13 [95% CI, 0.89-1.44]) were not statistically significant. Conclusions- A larger BP variability may be associated with a higher risk of having a higher burden of white matter hyperintensities. Targeting large BP variability has the potential to prevent cerebral small vessel disease and thereby reducing the risk of stroke and dementia. The potential issue of reverse causation and the heterogeneity in the assessment of cerebral small vessel disease markers should be better addressed in future studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.