Evidence map›Paper›PMID 31771450›Full record

ArticleJournal of the Royal Society, Interface2019

Mathematical modelling identifies the role of adaptive immunity as a key controller of respiratory syncytial virus in cotton rats.

Darren Wethington, Olivia Harder, Karthik Uppulury, William C L Stewart, Phylip Chen, Tiffany King, Susan D Reynolds, Alan S Perelson, Mark E Peeples, Stefan Niewiesk and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the Royal Society, Interface, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Treatment of Respiratory Viral Coinfections.Epidemiologia (Basel, Switzerland) · 2022
    Article
  7. Review
  8. Article
  9. Immune-viral dynamics modeling for SARS-CoV-2 drug development.Clinical and translational science · 2021
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Darren WethingtonBattelle Center for Mathematical Medicine, The Research Institute at the Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
Olivia HarderCollege of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
Karthik UppuluryBattelle Center for Mathematical Medicine, The Research Institute at the Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
William C L StewartBattelle Center for Mathematical Medicine, The Research Institute at the Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
Phylip ChenVaccines and Immunity, Abigail Wexner Research Institute at the Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
Tiffany KingVaccines and Immunity, Abigail Wexner Research Institute at the Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
Susan D ReynoldsCenter for Perinatal Research, Abigail Wexner Research Institute at the Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
Alan S PerelsonTheoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Mark E PeeplesVaccines and Immunity, Abigail Wexner Research Institute at the Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
Stefan NiewieskCollege of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
Jayajit DasBattelle Center for Mathematical Medicine, The Research Institute at the Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
Nationwide Children's Hospital · USThe Ohio State University · USLos Alamos National Laboratory · US

Funding

Collaborative Integration of HCV Molecular Virology and Mathematical ModelingR01AI078881 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PERELSON, ALAN S, UPRICHARD, SUSAN L. · 2011 to 2025
$7.5M
Project 3: Dr. LiP01AI112524 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI LI, JIANRONG · 2015 to 2019
$6.8M
Modeling Viral and T Lymphocyte DynamicsR01OD011095 · OD · TRIAD NATIONAL SECURITY, LLC · PI PERELSON, ALAN S · 2012 to 2024
$5.0M
Quantitative Determination of Ecological Niches for Polymicrobial Colonization inR01GM103612 · NIGMS · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI DAS, JAYAJIT · 2014 to 2017
$1.3M
NIAID NIH HHS P01 AI112524NIAID NIH HHS R01 AI078881NIGMS NIH HHS R01 GM103612NIH HHS R01 OD011095
6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) is a common virus that can have varying effects ranging from mild cold-like symptoms to mortality depending on the age and immune status of the individual. We combined mathematical modelling using ordinary differential equations (ODEs) with measurement of RSV infection kinetics in primary well-differentiated human bronchial epithelial cultures

Indexed as

Adaptive ImmunityModels, ImmunologicalAnimalsRespiratory Syncytial VirusesRespiratory Syncytial Virus InfectionsSigmodontinaeadaptive immunitycotton ratsnonlinear mixed effects modellingordinary differential equationsrespiratory syncytial virusviral kinetics

Identifiers

PMID31771450
PMCPMC6893489
OpenAlexW2989707811

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.