ArticleJournal of clinical medicine2019
The Influence of Histologic Inflammation on the Improvement of Liver Stiffness Values Over 1 and 3 Years.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Long-term prognosis and the need for histologic assessment of chronic hepatitis B in the serological immune-tolerant phase.Clinical and molecular hepatology · 2023Article
- Correspondence on Letter regarding "Long-term prognosis and the need for histologic assessment of chronic hepatitis B in the serological immune tolerant phase".Clinical and molecular hepatology · 2023Article
- Spleen stiffness determined by spleen-dedicated device accurately predicted esophageal varices in cirrhosis patients.Therapeutic advances in chronic disease · 2023Article
- Regression of liver fibrosis and hepatocellular carcinoma development after HCV eradication with oral antiviral agents.Scientific reports · 2022Observational
- A dynamic association between myosteatosis and liver stiffness: Results from a prospective interventional study in obese patients.JHEP reports : innovation in hepatology · 2021Article
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Authors and funding
13 authors.
Funding
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Abstract
backgroundTransient elastography is now an indispensable tool for estimating liver fibrosis. Although many clinical factors other than fibrosis itself are known to affect liver stiffness (LS) values, it is still not yet clear what factors are related to improving LS values. The aim of this study was to find out how baseline histologic inflammation influences LS values and how much this inflammation affects improvement in LS values over time, regardless of actual fibrosis content.
methodsThis retrospective study included 678 consecutive patients who underwent liver biopsy and sequential LS assessment from 2006 to 2015 at six tertiary hospitals in Korea. Linear regression analysis was used to evaluate how improvement of LS value can be associated with other factors besides fibrosis content.
resultsBasal LS values increased with increasing inflammation in the same fibrosis stage. Degree of inflammation influenced the baseline LS value in a proportional manner (beta coefficient (BE), 6.476; 95% confidence interval (CI), 2.24-10.72;
conclusionsThe LS value is affected by the degree of inflammation even at a low ALT level. Furthermore, baseline histologic inflammation has a significant impact on the improvement of LS values over time. Therefore, baseline inflammation should be taken into consideration when interpreting an improvement in LS value.
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