Evidence map›Paper›PMID 31771244›Full record

ReviewNutrients2019

Fat and Sugar-A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease.

Ines C M Simoes, Justyna Janikiewicz, Judith Bauer, Agnieszka Karkucinska-Wieckowska, Piotr Kalinowski, Agnieszka Dobrzyń, Andrzej Wolski, Maciej Pronicki, Krzysztof Zieniewicz, Paweł Dobrzyń and 4 more

Abstract readReview
In one paragraph

Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Review
  5. Article
  6. Evaluation of the Effects of Chia (Antioxidants (Basel, Switzerland) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ines C M SimoesNencki Institute of Experimental Biology of Polish Academy of Sciences, 02-093 Warsaw, Poland.
Justyna JanikiewiczNencki Institute of Experimental Biology of Polish Academy of Sciences, 02-093 Warsaw, Poland.
Judith BauerInstitute of Toxicology and Environmental Hygiene, Technical University Munich, School of Medicine, Biedersteiner Strasse 29, D-80802 Munich, Germany.
Agnieszka Karkucinska-WieckowskaDepartment of Pathology, The Children's Memorial Health Institute, 04-730 Warsaw, Poland.
Piotr KalinowskiDepartment of General, Transplant and Liver Surgery, Medical University of Warsaw, 02-091 Warsaw, Poland.
Agnieszka DobrzyńNencki Institute of Experimental Biology of Polish Academy of Sciences, 02-093 Warsaw, Poland.
Andrzej WolskiDepartment of Interventional Radiology and Neuroradiology, Medical University of Lublin, 20-090 Lublin, Poland.
Maciej PronickiDepartment of Pathology, The Children's Memorial Health Institute, 04-730 Warsaw, Poland.
Krzysztof ZieniewiczDepartment of General, Transplant and Liver Surgery, Medical University of Warsaw, 02-091 Warsaw, Poland.
Paweł DobrzyńNencki Institute of Experimental Biology of Polish Academy of Sciences, 02-093 Warsaw, Poland.
Marcin KrawczykLaboratory of Metabolic Liver Diseases, Department of General, Transplant and Liver Surgery, Laboratory of Metabolic Liver Diseases, Centre for Preclinical Research, Medical University of Warsaw, 02-091 Warsaw, Poland.
Hans ZischkaInstitute of Toxicology and Environmental Hygiene, Technical University Munich, School of Medicine, Biedersteiner Strasse 29, D-80802 Munich, Germany.
Mariusz R WieckowskiNencki Institute of Experimental Biology of Polish Academy of Sciences, 02-093 Warsaw, Poland.
Yaiza PotesNencki Institute of Experimental Biology of Polish Academy of Sciences, 02-093 Warsaw, Poland.

Funding

Deutsche Forschungsgemeinschaft ZI1386/2-1European Union's Horizon 2020 Research and Innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 722619 (FOIE GRAS)European Union's Horizon 2020 Research and Innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 734719 (mtFOIE GRAS)Narodowe Centrum Nauki UMO-2011/03/B/NZ4/03055Narodowe Centrum Nauki UMO-2013/10/E/NZ3/00670Narodowe Centrum Nauki UMO-2014/13/B/NZ4/00199Narodowe Centrum Nauki UMO-2015/19/D/NZ4/03705Narodowe Centrum Nauki UMO-2016/22/E/NZ4/00650Narodowe Centrum Nauki UMO-2018/29/B/NZ1/00589National Centre for Research and Development STRATEGMED3/305813/2/NCBR/2017
6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a common disease in Western society and ranges from steatosis to steatohepatitis to end-stage liver disease such as cirrhosis and hepatocellular carcinoma. The molecular mechanisms that are involved in the progression of steatosis to more severe liver damage in patients are not fully understood. A deeper investigation of NAFLD pathogenesis is possible due to the many different animal models developed recently. In this review, we present a comparative overview of the most common dietary NAFLD rodent models with respect to their metabolic phenotype and morphological manifestation. Moreover, we describe similarities and controversies concerning the effect of NAFLD-inducing diets on mitochondria as well as mitochondria-derived oxidative stress in the progression of NAFLD.

Indexed as

Lipid MetabolismAnimalsCholine DeficiencyDiabetes Mellitus, Type 2Dietary SugarsDiet, High-FatDiet, WesternDisease Models, AnimalDisease ProgressionFatty AcidsFatty LiverMiceMitochondria, LiverNon-alcoholic Fatty Liver DiseaseOxidative StressPhenotypeDietary SugarsFatty AcidsReactive Oxygen SpeciesmitochondriaNAFLD-inducing dietsnonalcoholic fatty liver diseaseoxidative stress

Identifiers

PMID31771244
PMCPMC6950566

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.