Evidence map›Paper›PMID 31771139›Full record

ArticleInternational journal of molecular sciences2019

Functional Impacts of the BRCA1-mTORC2 Interaction in Breast Cancer.

Kimiko L Krieger, Wen-Feng Hu, Tyler Ripperger, Nicholas T Woods

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

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  8. MicroRNA: a novel implication for damage and protection against ionizing radiation.Environmental science and pollution research international · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kimiko L KriegerEppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-7432-2729
Wen-Feng HuEppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Tyler RippergerEppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Nicholas T WoodsEppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
University of Nebraska Medical Center · USUniversity of Arizona · US

Funding

UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Joann B. Sweasy · 1985 to 2026
$55.0M
Target Validation CoreP20GM121316 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Robert E. Lewis · 2018 to 2026
$23.5M
CHEMICAL CARCINOGENESIS &CANCER BIOLOGYT32CA009476 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Jennifer D. Black · 1988 to 2026
$6.2M
Impact of BRCA1-mTORC2 interaction on breast cancer response to DNA damage and chR21CA184996 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WOODS, NICHOLAS TAYLOR · 2014 to 2015
$371k
NIH HHS P20GM121316NIH HHS P30CA036727NIH HHS R21CA184996NIH HHS T32CA009476
6 · The paper itself

Abstract

Deleterious mutations in Breast Cancer 1 (

Indexed as

BRCA1 ProteinBreast NeoplasmsCell Line, TumorCell SurvivalDNA DamageFluorescent Antibody TechniqueHumansIntracellular Signaling Peptides and ProteinsMechanistic Target of Rapamycin Complex 2PhosphorylationSignal TransductionTwo-Hybrid System TechniquesBRCA1 ProteinIntracellular Signaling Peptides and ProteinsMechanistic Target of Rapamycin Complex 2PRR5 protein, humanBRCA1BRCT domainDNA damage responsemTORC2 complexprotein-protein interactionsPRR5RICTORSIN1

Identifiers

PMID31771139
PMCPMC6928641
OpenAlexW2990904963

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.