ReviewInsects2019
Acetylcholine and Its Receptors in Honeybees: Involvement in Development and Impairments by Neonicotinoids.
Review in Insects, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 78 citations in OpenAlex.
- TRP channel activation and cholinergic signaling in insect thermoregulation: evidence from the American cockroach.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- The diversity of insecticide target site mutations in Apis mellifera.BMC genomics · 2026Article
- The Double-Edged Sword Effect of the Fibrinolytic System in Alzheimer's Disease.Cellular and molecular neurobiology · 2026Review
- Insecticide exposure alters feeding and impairs ovary development in a solitary bee.Ecotoxicology (London, England) · 2026Article
- Review
- Long-term fluorescence live imaging of honeybee embryos using light sheet fluorescence microscopy and halocarbon-based liquids.Biology open · 2025Article
- The Sublethal Effects of Neonicotinoids on Honeybees.Biology · 2025Review
- Acetylcholine and choline in honey bee (Apis mellifera) worker brood food are seasonal and age-dependent.Scientific reports · 2024Article
- Article
- Honey bee colony behavior and ontogeny are adversely affected when exposed to a pesticide-contaminated environment.Journal of insect science (Online) · 2024Article
- Larvicidal activity of Stemona collinsiae root extract against Musca domestica and Chrysomya megacephala.Scientific reports · 2023Article
- Multiomic interpretation of fungus-infected ant metabolomes during manipulated summit disease.Scientific reports · 2023Article
- Using machine learning to predict protein-protein interactions between a zombie ant fungus and its carpenter ant host.Scientific reports · 2023Article
- Chronic larval exposure to thiacloprid impairs honeybee antennal selectivity, learning and memory performances.Frontiers in physiology · 2023Article
- Selected Biochemical Markers Change after Oral Administration of Pesticide Mixtures in Honey Bees.Toxics · 2022Article
- Article
- Choline Transporter regulates olfactory habituation via a neuronal triad of excitatory, inhibitory and mushroom body neurons.PLoS genetics · 2021Article
- A Smartphone Camera Colorimetric Assay of Acetylcholinesterase and Butyrylcholinesterase Activity.Sensors (Basel, Switzerland) · 2021Article
- Nicotinic acetylcholine receptors: Ex-vivo expression of functional, non-hybrid, heteropentameric receptors from a marine arthropod, Lepeophtheirus salmonis.PLoS pathogens · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acetylcholine (ACh) is the major excitatory neurotransmitter in the insect central nervous system (CNS). However, besides the neuronal expression of ACh receptors (AChR), the existence of non-neuronal AChR in honeybees is plausible. The cholinergic system is a popular target of insecticides because the pharmacology of insect nicotinic acetylcholine receptors (nAChRs) differs substantially from their vertebrate counterparts. Neonicotinoids are agonists of the nAChR and are largely used in crop protection. In contrast to their relatively high safety for humans and livestock, neonicotinoids pose a threat to pollinating insects such as bees. In addition to its effects on behavior, it becomes increasingly evident that neonicotinoids affect developmental processes in bees that appear to be independent of neuronal AChRs. Brood food (royal jelly, worker jelly, or drone jelly) produced in the hypopharyngeal glands of nurse bees contains millimolar concentrations of ACh, which is required for proper larval development. Neonicotinoids reduce the secreted ACh-content in brood food, reduce hypopharyngeal gland size, and lead to developmental impairments within the colony. We assume that potential hazards of neonicotinoids on pollinating bees occur neuronally causing behavioral impairments on adult individuals, and non-neuronally causing developmental disturbances as well as destroying gland functioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.