ArticleJournal of neonatal-perinatal medicine2020
Correlations between oxygen and positive pressure exposure in the neonatal intensive care unit and wheezing in preterm infants without bronchopulmonary dysplasia.
Article in Journal of neonatal-perinatal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 1 citations in OpenAlex.
- Longitudinal developmental trajectories of weight-standardized lung function in preterm (28-36 + 6 weeks) vs. term infants and independent perinatal risk factors: a single-center prospective cohort study.Frontiers in pediatrics · 2026Article
- Predictors of recurrent wheezing in late preterm infants.Pediatric pulmonology · 2024Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundOxygen exposure has been associated with increased wheezing and respiratory morbidity after discharge in extremely preterm infants and those with bronchopulmonary dysplasia. More mature preterm infants with less severe disease are also at risk for pulmonary complications, including rehospitalization for respiratory illnesses and wheezing disorders. Our aim was to evaluate associations between respiratory support and morbidity in preterm infants without bronchopulmonary dysplasia.
methodsA secondary analysis was performed on 300 infants born at 28-34 weeks gestation without bronchopulmonary dysplasia. Exposure included oxygen or positive pressure, (continuous positive airway pressure or mechanical ventilation). The primary outcome was recurrent wheezing. Secondary outcomes were respiratory medications, emergency room visits, and hospitalizations.
results50% of infants who received oxygen experienced recurrent wheezing compared to 42.4% of infants who did not (OR 1.15 CI 0.72-1.85 adjusted OR 1.15 CI 0.67-1.98). 51.1% of infants who received positive pressure experienced recurrent wheezing compared to 38.1% who did not (OR 1.57 CI 0.97-2.53 adjusted OR 1.58 CI 0.90-2.77). There were no significant associations between oxygen and positive pressure exposure and any primary or secondary outcomes in the adjusted analyses.
conclusionsAfter adjustment for known risk factors the analyses showed no significant associations between oxygen and positive pressure with respiratory morbidity in this population. Further study of infants with mild disease is needed.
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