Evidence map›Paper›PMID 31771050›Full record

ArticleJournal of Alzheimer's disease : JAD2020

Brain Injury and Later-Life Cognitive Impairment and Neuropathology: The Honolulu-Asia Aging Study.

E Julia Chosy, Noele Gross, Marnie Meyer, Catherine Y Liu, Steven D Edland, Lenore J Launer, Lon R White

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

E Julia ChosyPacific Health Research and Education Institute, Honolulu, HI, USA.
Noele GrossPacific Health Research and Education Institute, Honolulu, HI, USA.
Marnie MeyerPacific Health Research and Education Institute, Honolulu, HI, USA.
Catherine Y LiuPacific Health Research and Education Institute, Honolulu, HI, USA.
Steven D EdlandUniversity of California at San Diego, San Diego, CA, USA.
Lenore J LaunerNational Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Lon R WhitePacific Health Research and Education Institute, Honolulu, HI, USA.
Pacific Health Research and Education Institute · USNational Institutes of Health · USUniversity of California, San Diego · US

Funding

Neuropathologic substrates for motor and cognitive impairment in three existing cohort studies of Alzheimer's disease and related dementiasUF1AG057707 · NIA · STANFORD UNIVERSITY · PI MONTINE, THOMAS J, WHITE, LON RAY · 2017 to 2017
$3.9M
Apolipoprotein E2 and Brain AgingRF1AG056499 · NIA · PACIFIC HEALTH RESEARCH/ EDUCATION INST · PI GOLDGABER, DMITRY Y, WHITE, LON RAY · 2017 to 2018
$3.4M
Brain aging and cardiovascular risk factors and diseaseZIAAG007480 · NIA · NATIONAL INSTITUTE ON AGING · PI LAUNER, LENORE J · 2011 to 2025
$2.7M
Cognitive resilience to Alzheimer neuropathologic changes in the Honolulu-Asia Aging Study and the Nun StudyUF1AG053983 · NIA · PACIFIC HEALTH RESEARCH/ EDUCATION INST · PI MONTINE, THOMAS J, WHITE, LON RAY · 2016 to 2016
$2.6M
INFLAMMATION IN DEMENTIAZ01AG007280 · NIA · NATIONAL INSTITUTE ON AGING · PI LAUNER, LENORE J · 2000 to 2008
$137k
Intramural NIH HHS Z01 AG007280NIA NIH HHS RF1 AG056499NIA NIH HHS UF1 AG053983NIA NIH HHS UF1 AG057707
6 · The paper itself

Abstract

backgroundFindings are inconsistent regarding the role of traumatic head injury in the subsequent development of neurologic outcomes.

objectiveExamine the relationship between head injury and later cognitive impairment.

methodsA sample of 3,123 Japanese-American men was assessed for history of head injury and evaluated for cognitive impairment using the Cognitive Abilities Screening Instrument (CASI). For a subsample of 676 respondents, neuropathologic results from those with and without head injury were compared.

resultsAlthough the crude model showed an association between history of head injury and later severe cognitive impairment, the relationship lost significance in the adjusted model (OR = 1.320, CI: 0.90-1.93), regardless of time between injury and impairment. Similar to cognitive impairment, hippocampal sclerosis was observed significantly more in the brains of respondents with a history of head injury in the crude model, but the relationship weakened in the adjusted model (OR = 1.462, CI: 0.68-3.12). After adjustment, decedents with a head injury demonstrated marginally higher brain weight (OR = 1.003, CI: 1.00-1.01).

conclusionWe did not find a relationship between head injury and subsequent cognitive decline in this cohort. The neuropathology results also displayed no strong association between history of head injury and specific brain lesions and characteristics. These results support other findings in prospective cohorts. However, they could be influenced by the demographic make-up of the sample (male Japanese-Americans) or by the observation that the majority reported only a single head injury.

Indexed as

AgedAged, 80 and overAsianBrain Injuries, TraumaticCognition DisordersCognitive DysfunctionHawaiiHippocampusHumansJapanMaleMiddle AgedNeuropsychological TestsOrgan SizeProspective StudiesSclerosisAlzheimer’s diseasebrain lesionscognitive dysfunctiondementiaHonolulu-Asia Aging Studyneuropathologytraumatic brain injury

Identifiers

PMID31771050
PMCPMC7477789
OpenAlexW2991126809

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.