Evidence map›Paper›PMID 31770722›Full record

ArticleAging2019

Latest advances in aging research and drug discovery.

Daniela Bakula, Andrea Ablasser, Adriano Aguzzi, Adam Antebi, Nir Barzilai, Martin-Immanuel Bittner, Martin Borch Jensen, Cornelis F Calkhoven, Danica Chen, Aubrey D N J de Grey and 20 more

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 20 institutions in 10 countries.

Daniela BakulaCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Andrea AblasserGlobal Health Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Adriano AguzziInstitute of Neuropathology, University of Zurich, Zurich, Switzerland.
Adam AntebiMax Planck Institute for Biology of Ageing, Cologne, Germany.
Nir BarzilaiDepartment of Medicine, Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Martin-Immanuel BittnerArctoris, Oxford, UK.
Martin Borch JensenGordian Biotechnology, San Francisco, CA 94107, USA.
Cornelis F CalkhovenEuropean Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, University of Groningen, AD Groningen, The Netherlands.
Danica ChenProgram in Metabolic Biology, Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA.
Aubrey D N J de GreySENS Research Foundation, Mountain View, CA 94041, USA.
Jerome N FeigeNestlé Research, EPFL Innovation Park, Lausanne, Switzerland.
Anastasia GeorgievskayaHaut.AI, Tallinn, Estonia.
Vadim N GladyshevDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Tyler GolatoMolecule, Basel, Switzerland.
Andrei V GudkovRoswell Park Comprehensive Cancer Center and Genome Protection, Inc., Buffalo, NY 14203, USA.
Thorsten HoppeInstitute for Genetics and CECAD Research Center, University of Cologne, Cologne, Germany.
Matt KaeberleinDepartment of Pathology, School of Medicine, University of Washington, Seattle, WA 98195, USA.
Pekka KatajistoDepartment of Biosciences and Nutrition, Center for Innovative Medicine, Karolinska Institutet, Huddinge, Sweden.
Brian K KennedyDepartments of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University Singapore, Singapore.
Unmesh LalFrost and Sullivan, Frankfurt am Main, Germany.
Ana Martin-VillalbaMolecular Neurobiology, German Cancer Research Center, Heidelberg, Germany.
Alexey A MoskalevEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Ivan OzerovPharmaceutical Artificial Intelligence Department, Insilico Medicine, Inc., Rockville, MD 20850, USA.
Michael A PetrCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
ReasonRepair Biotechnologies, Inc., Syracuse, NY 13210, USA.
David C RubinszteinDepartment of Medical Genetics, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge CB2 0XY, UK.
Alexander TyshkovskiyDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Quentin VanhaelenPharmaceutical Artificial Intelligence Department, Insilico Medicine, Inc., Rockville, MD 20850, USA.
Alex ZhavoronkovPharmaceutical Artificial Intelligence Department, Insilico Medicine, Inc., Rockville, MD 20850, USA.
Morten Scheibye-KnudsenCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Insilico Medicine (United States)University of Copenhagen · DKAlbert Einstein College of Medicine · USAllergan (Germany) · DEBrigham and Women's Hospital · USÉcole Polytechnique Fédérale de Lausanne · CHHarvard University · USHeidelberg University · DEMax Planck Institute for Biology of Ageing · DEMoscow Institute of Physics and Technology · RUNational University of Singapore · SGNestlé (Switzerland) · CHRoswell Park Comprehensive Cancer Center · USSENS Research Foundation · USUK Dementia Research Institute · GBUniversity of California, Berkeley · USUniversity of Cologne · DEUniversity of Groningen · NLUniversity of Helsinki · FIUniversity of Washington · US

Funding

SPECIFICITY OF OXYGEN DNA DAMAGE AND MUTAGENESISP01AG001751 · NIA · UNIVERSITY OF WASHINGTON · PI PRUSKY, GLEN THOMAS · 1985 to 2021
$29.6M
University of Washington Nathan Shock Center of Excellence in the Basic Biology of AgingP30AG013280 · NIA · UNIVERSITY OF WASHINGTON · PI Michael MacCoss · 1995 to 2026
$27.1M
Inflammation and Aging-associated DiabetesR01AG063389 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHEN, DANICA · 2019 to 2023
$2.0M
Nutrient Sensing, Hematopoietic Stem Cell Metabolism and AgingR01AG063404 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHEN, DANICA · 2018 to 2022
$2.0M
Hematopoietic Stem Cell AgingR01DK117481 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHEN, DANICA · 2018 to 2021
$1.7M
Obesity and HematopoiesisR01DK101885 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHEN, DANICA · 2015 to 2017
$942k
Medical Research Council UKDRI-2002NIA NIH HHS P01 AG001751NIA NIH HHS P30 AG013280NIA NIH HHS R01 AG063389NIA NIH HHS R01 AG063404NIDDK NIH HHS R01 DK101885NIDDK NIH HHS R01 DK117481
6 · The paper itself

Abstract

An increasing aging population poses a significant challenge to societies worldwide. A better understanding of the molecular, cellular, organ, tissue, physiological, psychological, and even sociological changes that occur with aging is needed in order to treat age-associated diseases. The field of aging research is rapidly expanding with multiple advances transpiring in many previously disconnected areas. Several major pharmaceutical, biotechnology, and consumer companies made aging research a priority and are building internal expertise, integrating aging research into traditional business models and exploring new go-to-market strategies. Many of these efforts are spearheaded by the latest advances in artificial intelligence, namely deep learning, including generative and reinforcement learning. To facilitate these trends, the Center for Healthy Aging at the University of Copenhagen and Insilico Medicine are building a community of Key Opinion Leaders (KOLs) in these areas and launched the annual conference series titled "Aging Research and Drug Discovery (ARDD)" held in the capital of the pharmaceutical industry, Basel, Switzerland (www.agingpharma.org). This ARDD collection contains summaries from the 6

Indexed as

AgingDrug DiscoveryResearchDrug IndustryHumansagingartificial intelligencedrug discovery

Identifiers

PMID31770722
PMCPMC6914421
OpenAlexW2990734878

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.