ArticleClinical immunology (Orlando, Fla.)2020
Occurrence of major anti-retinal autoantibodies associated with paraneoplastic autoimmune retinopathy.
Article in Clinical immunology (Orlando, Fla.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 54 citations in OpenAlex.
- Correlation between Antiretinal Antibodies and OCT Manifestations in Nonparaneoplastic Autoimmune Retinopathy.Ophthalmology science · 2026Article
- Immune Checkpoint Inhibitor-Induced Ocular Toxicity: A Case of Pembrolizumab-Associated Corneal Ulceration and Evisceration.Reports (MDPI) · 2025Article
- Correlation of Anti-TULP1 Autoantibodies with Breast Cancer and Autoimmune Retinopathy.International journal of molecular sciences · 2025Article
- Anti-retinal Autoantibodies in Hydroxychloroquine Eye Toxicity.ACR open rheumatology · 2025Article
- An unusual pAIR: Anti-PKM2 antibody and occult pancreatic adenocarcinoma.American journal of ophthalmology case reports · 2024Article
- Correlation of Functional and Structural Outcomes with Serum Antibody Profiles in Patients with Neovascular Age-Related Macular Degeneration Treated with Ranibizumab and Healthy Subjects: A Prospective, Controlled Monocenter Trial.Journal of clinical medicine · 2024Article
- Emerging Ocular Side Effects of Immune Checkpoint Inhibitors: A Comprehensive Review.Biomedicines · 2024Review
- Circulating Anti-Endothelial Cell Antibodies in Patients with Geographic Atrophy Related to Dry Age-Related Macular Degeneration.Medicina (Kaunas, Lithuania) · 2024Article
- Diagnosing and Managing Uveitis Associated with Immune Checkpoint Inhibitors: A Review.Diagnostics (Basel, Switzerland) · 2024Review
- Characterization of autoimmune eye disease in association with Down's syndrome.Eye (London, England) · 2024Article
- Serum antiretinal antibodies and cytokine profiling in autoimmune retinopathy and their association with clinical outcomes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Characterization of autoimmune eye disease in association with Down's Syndrome.Research square · 2023Article
- Relation between ocular paraneoplastic syndromes and Immune Checkpoint Inhibitors (ICI): review of literature.Journal of ophthalmic inflammation and infection · 2023Review
- Pediatric autoimmune retinopathy and optic neuropathy: a case report and a review of the literature.Frontiers in ophthalmology · 2023Article
- Limited Clinical Value of Anti-Retinal Antibody Titers and Numbers in Autoimmune Retinopathy.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- Paraneoplastic syndrome in neuroophthalmology.Journal of neurology · 2022Review
- Immunotherapy-induced retinopathy mimicking cancer associated retinopathy.American journal of ophthalmology case reports · 2022Article
- Autoimmune retinopathy: clinical, electrophysiological, and immunological features in nine patients with long-term follow-up.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- Cancer-associated retinopathy after anti-programmed death 1 (PD-1) antibody for treating hepatocellular carcinoma--a case report of a Chinese patient.American journal of ophthalmology case reports · 2022Article
- Autoimmune Retinopathy, Testing, and Its Controversies.Current ophthalmology reports · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Autoantibodies (AAbs) against retinal antigens can be found in patients with cancer and unexplained vision loss unrelated to the cancer metastasis. Cancer-associated retinopathy (CAR) is a rare paraneoplastic visual syndrome mediated by AAbs. Our goal was to determine whether CAR patients with different malignancies have a specific AAb or repertoire of AAbs that could serve as biomarkers for retinal disease. We found AAbs against 12 confirmed retinal antigens, with α-enolase being the most frequently recognized. The significant finding of the study was a high incidence of anti-aldolase AAbs in colon-CAR, anti-CAII in prostate-CAR, and anti-arrestin in skin melanoma patients thus these AAbs could serve as biomarkers in the context of clinical presentation and could support the diagnosis of CAR. However, a lack of AAb restriction to any one antigenic protein or to one retinal cellular location makes screening for a CAR biomarker challenging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.