ArticlePloS one2019
Association between advanced maternal age and maternal and neonatal morbidity: A cross-sectional study on a Spanish population.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Maternal age 30-34 years and adverse perinatal outcomes: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Adverse maternal outcomes and associated factors among mothers of advanced age delivering at a tertiary hospital, southwestern Uganda: a cross-sectional study.BMC pregnancy and childbirth · 2024Article
- [Maternal and perinatal morbidities associated to advanced age in pregnant women].Revista medica del Instituto Mexicano del Seguro Social · 2023Observational
- Is There an Age Limit for a Trial of Vaginal Delivery in Nulliparous Women?Journal of clinical medicine · 2023Article
- The interaction between age and parity on adverse pregnancy and neonatal outcomes.Frontiers in medicine · 2023Article
- Effect of advanced parental age on pregnancy outcome and offspring health.Journal of assisted reproduction and genetics · 2022Review
- Nutritional Health Education in Pregnant Women in a Rural Health Centre: Results in Spanish and Foreign Women.Healthcare (Basel, Switzerland) · 2021Article
- Exploring women's experiences of participation in shared decision-making during childbirth: a qualitative study at a reference hospital in Spain.BMC pregnancy and childbirth · 2021Article
- Advance Age Pregnancy in a Tertiary Care Centre: A Descriptive Cross-sectional Study.JNMA; journal of the Nepal Medical Association · 2021Article
- circCRAMP1L is a novel biomarker of preeclampsia risk and may play a role in preeclampsia pathogenesis via regulation of the MSP/RON axis in trophoblasts.BMC pregnancy and childbirth · 2020Observational
- Associations Between Delivery Mode and Early Childhood Body Mass Index Z-Score Trajectories: A Retrospective Analysis of 2,685 Children From Mothers Aged 18 to 35 Years at Delivery.Frontiers in pediatrics · 2020Article
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5 authors.
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Abstract
BACKGROUND AND
objectiveOver recent decades, a progressive increase in the maternal age at childbirth has been observed in developed countries, posing a health risk for both women and infants. The aim of this study was to analyze the association between advanced maternal age (AMA) and maternal and neonatal morbidity. MATERIAL AND
methodsA cross-sectional study of 3,315 births was conducted in the north of Spain in 2014. We compared childbirth between women aged 35 years or older, with a reference group of women aged between 24 and 27 years. AMA was categorized based on ordinal ranking into 35-38 years, 39-42 years, and >42 years to estimate a dose-response pattern (the older the age, the greater the risk). As an association measure, crude and adjusted Odds Ratios (OR) were estimated by non-conditional logistic regression and 95% Confidence Intervals (95%CI) were calculated.
resultsRepeated abortions were more common among women of AMA in comparison to pregnant women aged 24-27 years (reference group): adjusted OR = 2.68; 95%CI (1.52-4.73). A higher prevalence of gestational diabetes was also observed among women of AMA, reaching statistical significance when restricted to first time mothers: adjusted OR = 8.55; 95%CI (1.12-65.43). In addition, the possibility of an instrumental delivery was multiplied by 1.6 and the possibility of a cesarean by 1.5 among women of AMA, with these results reaching statistical significance, and observing a dose-response pattern. Lastly, there were associations between preeclampsia, preterm birth (<37 weeks) and low birthweight, however without reaching statistical significance.
conclusionOur results support the association between AMA and suffering repeated abortions. Likewise, being of AMA was associated with a greater risk of suffering from gestational diabetes, especially among primiparous women, as well as being associated with both instrumental deliveries and cesareans among both primiparous and multiparous women.
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