Evidence map›Paper›PMID 31770217›Full record

SynthesisMedicine2019

Prognostic and clinicopathological significance of long non-coding RNA UCA1 in colorectal cancer: Results from a meta-analysis.

Xiaoqun Liu, Xiangdong Liu, Tiankui Qiao, Wei Chen

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Xiaoqun LiuCenter for Tumor Diagnosis and Therapy.
Xiangdong LiuDepartment of Ophthalmology, Jinshan Hospital, Fudan University, Shanghai, China.
Tiankui QiaoCenter for Tumor Diagnosis and Therapy.
Wei ChenCenter for Tumor Diagnosis and Therapy.
National Center for Tumor Diseases · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveUrothelial cancer-associated 1 (UCA1), an oncogenic long non-coding RNA, was aberrantly upregulated in colorectal cancer (CRC). This study aimed to further explore the clinical value of UCA1 in CRC.

methodsEligible studies were retrieved by searching Pubmed, Embase, Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure, and Wanfang databases. Pooled hazard ratio (HR) and odds ratio (OR) with 95% confidence interval (CI) were applied to assess the prognostic role and clinical significance of UCA1.

resultsA total of 7 eligible studies with 775 cancer patients were recruited in the meta-analysis. The results showed that UCA1 overexpression was significantly correlated with poor overall survival in patients with CRC (HR = 2.25, 95% CI: 1.77-2.87, P < .001). There was also a significantly negative association between high UCA1 levels and tumor differentiation (OR = 2.84, 95% CI: 1.87-4.31, P < .001), lymph node metastasis (OR = 3.48, 95% CI: 2.24-5.41, P < .001), distant metastasis (OR = 2.67, 95% CI: 1.32-5.38, P = .006), tumor node metastasis stage (OR = 3.01, 95% CI: 2.16-4.18, P < .001), tumor invasion depth (OR = 2.18, 95% CI: 1.03-4.61, P = .04), and tumor size (OR = 2.27, 95% CI: 1.56-3.32, P < .001).

conclusionsOur study revealed that UCA1 overexpression was associated with poor prognosis and more advanced clinicopathological features, suggesting that UCA1 may serve as an indicator for unfavorable outcome of patients with CRC.

Indexed as

Biomarkers, TumorColorectal NeoplasmsDisease-Free SurvivalGene Expression Regulation, NeoplasticHumansLymphatic MetastasisNeoplasm InvasivenessNeoplasm MetastasisNeoplasm StagingOdds RatioPrognosisProportional Hazards ModelsRNA, Long NoncodingTumor BurdenUp-RegulationBiomarkers, TumorRNA, Long NoncodingUCA1 RNA, human

Identifiers

PMID31770217
PMCPMC6890311
OpenAlexW2991113647

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.