Evidence map›Paper›PMID 31770070›Full record

ReviewViral immunology2020

What Targets Somatic Hypermutation to the Immunoglobulin Loci?

Justin M H Heltzel, Patricia J Gearhart

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Viral immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Promoter Proximity Defines Mutation Window for VJournal of immunology (Baltimore, Md. : 1950) · 2022
    Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Justin M H HeltzelLaboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Patricia J GearhartLaboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
National Institute on Aging · USNational Institutes of Health · US

Funding

Roles for Transcription in Antibody DiversityZIAAG000714 · NIA · NATIONAL INSTITUTE ON AGING · PI GEARHART, PATRICIA J · 2009 to 2025
$10.9M
6 · The paper itself

Abstract

One of the most profound enigmas in B cell biology is how activation-induced deaminase (AID) is targeted to a very small region of DNA in the immunoglobulin loci. Two specific regions are singled out: the variable region of 2 kb that contains rearranged genes on the heavy,

Indexed as

AICDA (Activation-Induced Cytidine Deaminase)B-LymphocytesChromosomal Proteins, Non-HistoneCytidine DeaminaseEnhancer Elements, GeneticGC Rich SequenceGenetic LociHumansImmunoglobulin Class SwitchingImmunoglobulin Heavy ChainsRNA Polymerase IISomatic Hypermutation, ImmunoglobulinTranscriptional Elongation FactorsTranscription, GeneticAICDA (Activation-Induced Cytidine Deaminase)Chromosomal Proteins, Non-HistoneCytidine DeaminaseImmunoglobulin Heavy ChainsRNA Polymerase IISPT5 transcriptional elongation factorTranscriptional Elongation FactorsAIDclass switch recombinationsomatic hypermutationtranscription

Identifiers

PMID31770070
PMCPMC7247024
OpenAlexW2990445354

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.