ArticleACS chemical biology2019
Fitness Factors for Bioorthogonal Chemical Probes.
Article in ACS chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Optimization of the genetic code expansion technology for intracellular labelling and single-molecule tracking of proteins in genomically re-codedRSC chemical biology · 2026Article
- Bioorthogonal Chemistry in Biomolecule Quantification: A Review of Reactions and Strategies.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Protein Modification via Bioorthogonal HS-BCN Ligation.Methods in molecular biology (Clifton, N.J.) · 2026Article
- An Iron-Catalyzed Sustainable Functional Group Transfer Strategy for In-Water Transformation of Organic Sulfides to Sulfoxides by a Hydroxylamine-Derived Oxidant.ChemSusChem · 2025Article
- Insights into receptor structure and dynamics at the surface of living cells.Nature communications · 2023Article
- The thiol-sulfoxonium ylide photo-click reaction for bioconjugation.Chemical science · 2023Article
- Photoreactive bioorthogonal lipid probes and their applications in mammalian biology.RSC chemical biology · 2023Article
- Seeking Citius: Photochemical Access of Reactive Intermediates for Faster Bioorthogonal Reactions.Chembiochem : a European journal of chemical biology · 2022Article
- Fluorogenic Cyclopropenones for Multicomponent, Real-Time Imaging.Journal of the American Chemical Society · 2022Article
- Superfast Tetrazole-BCN Cycloaddition Reaction for Bioorthogonal Protein Labeling on Live Cells.Journal of the American Chemical Society · 2022Article
- Intracellular bioorthogonal labeling of glucagon receptor via tetrazine ligation.Bioorganic & medicinal chemistry · 2021Article
- Bioorthogonal Hydroamination of Push-Pull-Activated Linear Alkynes.Angewandte Chemie (International ed. in English) · 2021Article
- Diverse protein manipulations with genetically encoded glutamic acid benzyl ester.Chemical science · 2021Article
- Bioorthogonal chemistry.Nature reviews. Methods primers · 2021Article
- Covalent labeling of nucleic acids.Chemical Society reviews · 2020Review
- Bioorthogonal Ligations and Cleavages in Chemical Biology.ChemistryOpen · 2020Review
- Labelling of DNA and RNA in the cellular environment by means of bioorthogonal cycloaddition chemistry.RSC chemical biology · 2020Review
- Developing bioorthogonal probes to span a spectrum of reactivities.Nature reviews. Chemistry · 2020Article
- Fluorescent bioorthogonal labeling of class B GPCRs in live cells.Methods in enzymology · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Bioorthogonal chemistry has offered an invaluable reactivity-based tool to chemical biology owing to its exquisite specificity in tagging a diverse set of biomolecules in their native environment. Despite tremendous progress in the field over the past decade, designing a suitable bioorthogonal chemical probe to investigate a given biological system remains a challenge. In this Perspective, we put forward a series of fitness factors that can be used to assess the performance of bioorthogonal chemical probes. The consideration of these criteria should encourage continuous innovation in bioorthogonal probe development as well as enhance the quality of biological data.
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Registered trials
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