ReviewCirculation2019
Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop
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In one paragraph
Review in Circulation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 2% of its field
What it found
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Who cites it
85 citing papers in PubMed, 1 synthesis or guideline pooled it, 131 citations in OpenAlex.
- The Effects of Exercise Training on Mitochondrial Function in Cardiovascular Diseases: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2022Pooled it
- Simvastatin Combined with Resistance Training Improves Outcomes in Patients with Chronic Heart Failure by Modulating Mitochondrial Membrane Potential and the Janus Kinase/Signal Transducer and Activator of Transcription 3 Signaling Pathways.Cardiovascular therapeutics · 2022Trial
- Mitochondrial superoxide-induced mitohormesis is mediated by citrate and cardioprotective.Science advances · 2026Article
- Plasma Metabolite Associations with Incident Heart Failure with Reduced and Preserved Ejection Fraction.medRxiv : the preprint server for health sciences · 2026Article
- ROMO1 and mitochondrial complex II/SDH are required for spare respiratory capacity and glucose homeostasis in mice.Diabetologia · 2026Article
- Heart failure in the elderly: epidemiology, mechanisms, and management.European heart journal · 2026Review
- CRISPR-Cas-based activation of PPARGC1A boosts endogenous mitochondria and enhances cardiac function after myocardial infarction.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Novel Allogeneic Mitochondria and Associated Organelle Complex Treatment Prevents Myocardial Ischemia-Reperfusion Injury Through Anti-Apoptotic Effects.JACC. Asia · 2026Article
- TIGAR deficiency enhances cardiac resilience through epigenetic programming of Parkin expression.JCI insight · 2026Article
- Cardiovascular ageing: hallmarks, signaling pathways, diseases and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- The core mechanism of traditional Chinese medicine in improving myocardial fibrosis: restoring the dynamic balance of mitochondrial quality control.Frontiers in cardiovascular medicine · 2026Review
- High-intensity interval training improves mitochondrial function and attenuates cardiomyocytes damage in ischemia-reperfusion.International journal of cardiology. Heart & vasculature · 2025Review
- PGC1α regulates the mitochondrial metabolism response to cyclic stretch, which inhibits neointimal hyperplasia.Cellular and molecular life sciences : CMLS · 2025Article
- Promotion of pathological cardiac remodeling by excessive mitochondrial fission in physical inactivity and myocardial infarction.Scientific reports · 2025Article
- SGLT2 inhibitor upregulates myocardial genes for oxidative phosphorylation and fatty acid metabolism in Gαq-mice.Journal of molecular and cellular cardiology plus · 2025Article
- Colonization withbioRxiv : the preprint server for biology · 2025Article
- Astragaloside IV Alleviates HCardiovascular therapeutics · 2025Article
- Inter- and intracellular mitochondrial communication: signaling hubs in aging and age-related diseases.Cellular & molecular biology letters · 2024Review
- Cytokine Adsorption During Ex Vivo Blood Perfusion Improves Contractility of Donation After Circulatory Death Hearts.Journal of the American Heart Association · 2024Article
- An optimized Langendorff-free method for isolation and characterization of primary adult cardiomyocytes.BMC cardiovascular disorders · 2024Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors at 20 institutions in 4 countries.
Rong TianMitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle.
Wilson S. ColucciDepartment of Medicine, Boston University, MA.
Zoltan AranyDepartment of Medicine, University of Pennsylvania, Philadelphia.
Markus M. BachschmidDepartment of Medicine, Boston University, MA.
Scott W. BallingerDepartment of Pathology, University of Alabama at Birmingham.
Sihem BoudinaDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City.
James E. BruceDepartment of Genome Sciences, University of Washington, Seattle.
David W. BusijaDepartment of Pharmacology, Tulane University, New Orleans, LA.
Sergey DikalovDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Gerald W. DornCenter for Pharmacogenomics, Department of Internal Medicine, Washington University, St. Louis, MO.
Zorina S. GalisNational, Heart, Lung, and Blood Institute, National Institutes
of Health, Bethesda, MD.
Roberta A. GottliebSmidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
Daniel P. KellyDepartment of Medicine, University of Pennsylvania, Philadelphia.
Richard N. KitsisDepartment of Medicine, Department of Cell Biology, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY.
Mark J. KohrDepartments of Environmental Health and Engineering, The Johns Hopkins University, Baltimore, MD.
Daniel LevyNational, Heart, Lung, and Blood Institute, National Institutes
of Health, Bethesda, MD.
E. Douglas LewandowskiDepartment of Internal Medicine, The Ohio State University, Columbus.
Joseph M. McClungDepartment of Physiology, East Carolina University, Greenville, NC.
Daria Mochly-RosenDepartment of Chemical and Systems Biology, Stanford University, CA.
Kevin D. O'BrienDepartment of Medicine, University of Washington, Seattle.
Brian O'RourkeDepartment of Medicine, The Johns Hopkins University, Baltimore, MD.
Joon-Young ParkDepartment of Kinesiology, Temple University, Philadelphia, PA.
Peipei PingDepartment of Physiology and Department of Medicine, University of California, Los Angeles.
Michael N. SackNational, Heart, Lung, and Blood Institute, National Institutes
of Health, Bethesda, MD.
Shey-Shing SheuDepartment of Medicine, Thomas Jefferson University, Philadelphia, PA.
Yang ShiNational, Heart, Lung, and Blood Institute, National Institutes
of Health, Bethesda, MD.
Sruti ShivaDepartment of Pharmacology and Chemical Biology and Vascular Medicine Institute, University of Pittsburgh, PA.
Douglas C. WallaceCenter for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia Research Institute, PA.
Robert G. WeissDepartment of Medicine, The Johns Hopkins University, Baltimore, MD.
Hilary J. VernonDepartment of Genetic Medicine, The Johns Hopkins University, Baltimore, MD.
Renee WongNational, Heart, Lung, and Blood Institute, National Institutes
of Health, Bethesda, MD.
Lisa Schwartz LongacreNational, Heart, Lung, and Blood Institute, National Institutes
of Health, Bethesda, MD.
National Heart Lung and Blood Institute · USJohns Hopkins University · USBoston University · USUniversity of Pittsburgh · USUniversity of Washington · USAlbert Einstein College of Medicine · USCedars-Sinai Smidt Heart Institute · USChildren's Hospital of Philadelphia · USColumbus State University · USEast Carolina University · USMRC Mitochondrial Biology Unit · GBPhiladelphia Zoo · USStanford University · USTemple University · USThomas Jefferson University · USTulane University · USUniversity of Alabama at Birmingham · USUniversity of California, Los Angeles · USUniversity of Pennsylvania · USUniversity of Utah · US
Funding
Project-005UL1TR001430 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BAIR-MERRITT, MEGAN H, CENTER, DAVID M. · 2015 to 2024
$52.3MRole of Serum Amyloid A in Diabetic Vascular DiseaseP01HL092969 · NHLBI · UNIVERSITY OF WASHINGTON · PI CHAIT, ALAN · 2008 to 2019
$23.5MUniversity of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5MProtein Chemistry and ProteomicsP01HL112730 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI VAN EYK, JENNIFER E · 2013 to 2017
$12.0MREGULATION OF FATTY ACID OXIDATION DURING CARDIAC GROWTHR01HL058493 · NHLBI · WASHINGTON UNIVERSITY · PI KELLY, DANIEL PATRICK · 1998 to 2024
$10.6MProtein Kinase C Isozymes in Ischemic HeartR01HL052141 · NHLBI · STANFORD UNIVERSITY · PI MOCHLY-ROSEN, DARIA · 1996 to 2021
$8.5MMECHANISMS OF ETHANOL-INDUCED CARDIAC PROTECTIONR01AA011147 · NIAAA · STANFORD UNIVERSITY · PI DARIA MOCHLY-ROSEN · 1996 to 2026
$8.2MCONTRIBUTION OF ENERGY DEPLETION TO HUMAN HEART FAILURER01HL061912 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI WEISS, ROBERT G · 1999 to 2020
$8.0MMITOCHONDRIAL INBORN ERRORS OF METABOLISMR01NS021328 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI WALLACE, DOUGLAS C · 1985 to 2017
$6.5MTHE MITOCHONDRIAL DYNAMISM/FITNESS/BIOGENESIS INTERACTOME IN CARDIAC DISEASER35HL135736 · NHLBI · WASHINGTON UNIVERSITY · PI DORN, GERALD W. · 2017 to 2023
$6.4MProbing the Role of Mitochondrial Short-chain Carbon Homeostasis in the Hypertrophied and Failing HeartR01HL128349 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MUOIO, DEBORAH M · 2016 to 2024
$6.1MNAD+/NADH ratio, protein acetylation and mitochondrial functionR01HL110349 · NHLBI · UNIVERSITY OF WASHINGTON · PI TIAN, RONG · 2011 to 2020
$5.7MAmerican Heart Association-American Stroke Association 16GRNT27660006Intramural NIH HHS Z99 HL999999NCATS NIH HHS UL1 TR001430NHLBI NIH HHS N01 HV028178NHLBI NIH HHS P01 HL092969NHLBI NIH HHS P01 HL112730NHLBI NIH HHS R01 HL049244NHLBI NIH HHS R01 HL052141NHLBI NIH HHS R01 HL058493NHLBI NIH HHS R01 HL061912NHLBI NIH HHS R01 HL063030NHLBI NIH HHS R01 HL064750NHLBI NIH HHS R01 HL093671NHLBI NIH HHS R01 HL110349NHLBI NIH HHS R01 HL113057NHLBI NIH HHS R01 HL122124NHLBI NIH HHS R01 HL124116NHLBI NIH HHS R01 HL125695NHLBI NIH HHS R01 HL126952NHLBI NIH HHS R01 HL128071NHLBI NIH HHS R01 HL128349NHLBI NIH HHS R01 HL129510NHLBI NIH HHS R01 HL130861NHLBI NIH HHS R01 HL132075NHLBI NIH HHS R01 HL132525NHLBI NIH HHS R01 HL133003NHLBI NIH HHS R01 HL134821NHLBI NIH HHS R01 HL136496NHLBI NIH HHS R01 HL137259NHLBI NIH HHS R01 HL137266NHLBI NIH HHS R01 HL137426NHLBI NIH HHS R01 HL138475NHLBI NIH HHS R01 HL142628NHLBI NIH HHS R01 HL142864NHLBI NIH HHS R01 HL144509NHLBI NIH HHS R01 HL144778NHLBI NIH HHS R01 HL144937NHLBI NIH HHS R21 HL126209NHLBI NIH HHS R35 HL135736NIDDK NIH HHS P30 DK079626NIDDK NIH HHS R01 DK098646NIDDK NIH HHS R01 DK100826NIDDK NIH HHS R01 DK103750NIGMS NIH HHS R01 GM086688NIGMS NIH HHS R01 GM113816NIH HHS R01 OD010944NIMH NIH HHS R01 MH108592NINDS NIH HHS R01 NS021328
Abstract
Mitochondria have emerged as a central factor in the pathogenesis and progression of heart failure, and other cardiovascular diseases, as well, but no therapies are available to treat mitochondrial dysfunction. The National Heart, Lung, and Blood Institute convened a group of leading experts in heart failure, cardiovascular diseases, and mitochondria research in August 2018. These experts reviewed the current state of science and identified key gaps and opportunities in basic, translational, and clinical research focusing on the potential of mitochondria-based therapeutic strategies in heart failure. The workshop provided short- and long-term recommendations for moving the field toward clinical strategies for the prevention and treatment of heart failure and cardiovascular diseases by using mitochondria-based approaches.
Indexed as
Cardiovascular SystemNational Heart, Lung, and Blood Institute (U.S.)Research ReportBiomedical ResearchEducationHeart FailureHumansMitochondriaTranslational Research, BiomedicalUnited Statescardiovascular diseasesheart failuremitochondria
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