ArticleJournal of diabetes2020
Insulin resistance is associated with urinary albumin-creatinine ratio in normal weight individuals with hypertension and diabetes: The REACTION study.
Article in Journal of diabetes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 47 citations in OpenAlex.
- Close relationship between β2-microglobulin and type 2 diabetes-associated peripheral neuropathy.Journal of diabetes investigation · 2026Article
- Determinants of estimated glomerular filtration rate in patients with type 2 diabetes mellitus: A cross-sectional study.Biomedical reports · 2025Article
- Joint association of urinary albumin-to-creatinine ratio within normal range and triglyceride-glucose index with incident cardiovascular disease: a prospective cohort study.Cardiovascular diabetology · 2025Article
- Risk factors for progression to albuminuria in individuals with newly diagnosed type 2 diabetes: a 5-year cohort study.BMC endocrine disorders · 2025Observational
- Association of the triglyceride glucose index with obesity indicators and hypertension in American adults based on NHANES 2013 to 2018.Scientific reports · 2025Article
- Risk Evaluation of Progression of Proteinuria and Renal Decline Based on a Novel Subgroup Classification in Chinese Patients with Type 2 Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025Article
- Association of remnant cholesterol with decreased kidney function or albuminuria: a population-based study in the U.S.Lipids in health and disease · 2024Article
- Association between the triglyceride-glucose index and 1-year major adverse cardiovascular events in patients with coronary heart disease and hypertension.Cardiovascular diabetology · 2023Article
- Copper(II) Affects the Biochemical Behavior of Proinsulin C-peptide by Forming Ternary Complexes with Serum Albumin.Journal of the American Chemical Society · 2023Article
- Article
- Comparison of insulin resistance indices in predicting albuminuria among patients with type 2 diabetes.European journal of medical research · 2023Article
- Association between the triglyceride-glucose index and chronic kidney disease in adults.International urology and nephrology · 2023Article
- The Impact of COVID-19 Pandemic Lockdown on the Relationship between Pediatric MAFLD and Renal Function.Journal of clinical medicine · 2023Article
- The relationship between triglyceride-glucose index and albuminuria in United States adults.Frontiers in endocrinology · 2023Article
- Relationship between Leptin and Insulin Resistance among Community-Dwelling Middle-Aged and Elderly Populations in Taiwan.Journal of clinical medicine · 2022Article
- Concomitant treatment with insulin and sodium-glucose cotransporter 2 inhibitors was associated with the renal composite outcome in Japanese patients with type 2 diabetes and chronic kidney disease: A propensity score-matched analysis.Journal of diabetes investigation · 2022Article
- Multiparametric magnetic resonance imaging allows non-invasive functional and structural evaluation of diabetic kidney disease.Clinical kidney journal · 2022Article
- Association of Dietary Fish and n-3 Unsaturated Fatty Acid Consumption with Diabetic Nephropathy from a District Hospital in Northern Taiwan.Nutrients · 2022Article
- Article
- Metabolism Score for Visceral Fat (METS-VF): A New Predictive Surrogate for CKD Risk.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
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Authors and funding
5 authors at 4 institutions in 1 country.
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Abstract
backgroundThe relationship between albuminuria and insulin resistance (IR) has not been clarified in previous studies. This study was conducted to examine whether IR is associated with albuminuria in subjects with diverse blood pressure and glycometabolism statuses.
methodsThis study included 34 136 participants whose data were drawn from a cross-sectional survey named the 2011 REACTION study. The participants were divided into six groups. The urinary albumin-creatinine ratio (UACR) and glomerular filtration rate (GFR) were used as markers of chronic kidney disease (CKD). Variance tests and logistic regression models were performed for homeostatic model assessment of insulin resistance (HOMA-IR) in relation to UACR and eGFR.
resultsFirst, UACR levels and HOMA-IR exhibited a positive correlation among participants (P < 0.05), and a negative correlation existed between GFR and HOMA-IR (P < 0.05). Second, in the hypertension with diabetes group, in individuals whose body mass index (BMI) was 18.5-24.0 kg/m
conclusionsIn the context of different blood pressure and glycometabolism statuses, the positive correlation between UACR levels and HOMA-IR was affected by BMI, age, LDL-C, HDL-C, and GFR. In patients with hypertension and diabetes, the early detection and intervention of IR and related risk factors in patients with normal BMI may reduce the occurrence of microalbuminuria and delay the progression of CKD.
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