Evidence map›Paper›PMID 31769755›Full record

ArticleeLife2019

Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane composition and fluidity.

Mario Ruiz, Rakesh Bodhicharla, Marcus Ståhlman, Emma Svensk, Kiran Busayavalasa, Henrik Palmgren, Hanna Ruhanen, Jan Boren, Marc Pilon

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Exploring the Role ofACS infectious diseases · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Forward genetics ineLife · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Mario Ruiz *Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.
Rakesh Bodhicharla *Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.
Marcus StåhlmanDepartment of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-4202-0339
Emma SvenskDepartment of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.
Kiran BusayavalasaDepartment of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.
Henrik PalmgrenMetabolism BioScience, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Hanna RuhanenHelsinki University Lipidomics Unit, Helsinki Institute for Life Science, Helsinki, Finland.
Jan BorenDepartment of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Marc PilonDepartment of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0003-3919-2882
University of Gothenburg · SEAstraZeneca (Sweden) · SEUniversity of Helsinki · FI

Funding

Cancerfonden Dnr 16 0693Carl Tryggers Stiftelse för Vetenskaplig Forskning CTS 16:365Diabetesfonden DIA2016-109Vetenskapsrådet Dnr: 2016-03676
6 · The paper itself

Abstract

The human AdipoR1 and AdipoR2 proteins, as well as their

Indexed as

Evolution, MolecularAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell MembraneCoenzyme A LigasesConserved SequenceHumansLong-Chain-Fatty-Acid-CoA LigaseMembrane FluidityMembrane ProteinsMutationPhenotypeReceptors, AdiponectinRNA, Small InterferingACSL1 protein, humanADIPOR1 protein, humanADIPOR2 protein, humanCaenorhabditis elegans ProteinsCoenzyme A LigasesLong-Chain-Fatty-Acid-CoA LigaseMembrane ProteinsPAQR-2 protein, C elegansReceptors, AdiponectinRNA, Small Interferingacyl-coA synthetaseadiponectin receptorC. eleganscell biologycell membraneforward geneticshumanlipidomicsphospholipids

Identifiers

PMID31769755
PMCPMC6901333
OpenAlexW2989911530

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.