ReviewCancers2019
Cachexia and Sarcopenia in Older Adults with Cancer: A Comprehensive Review.
Review in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
97 citing papers in PubMed, 7 syntheses or guidelines pooled it, 176 citations in OpenAlex.
- Functional Outcomes and Quality of Life for Patients With Cachexia and Solid Tumour Cancers: Findings of a Systematic Literature Review.Journal of cachexia, sarcopenia and muscle · 2026Pooled it
- Assessment of correlation between conventional anthropometric and imaging-derived measures of body fat composition: a systematic literature review and meta-analysis of observational studies.BMC medical imaging · 2023Pooled it
- Sarcopenia as a prognostic indicator in colorectal cancer: an updated meta-analysis.Frontiers in oncology · 2023Pooled it
- Patient reported outcomes in oncology: changing perspectives-a systematic review.Health and quality of life outcomes · 2022Pooled it
- Pooled it
- Sarcopenia predicts adverse outcomes in an elderly population with coronary artery disease: a systematic review and meta-analysis.BMC geriatrics · 2021Pooled it
- Pooled it
- Effects of high-protein nutritional supplementation on nutritional status, physical function, and quality of life in older gastric cancer patients receiving neoadjuvant chemotherapy: a randomized trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Trial
- Effect of a new plant-based high-energy oral nutritional supplement in adult malnourished patients: an open-label, randomized clinical trial.Frontiers in nutrition · 2025Trial
- Impact of Hypertrophy-Oriented Resistance Training on Muscle Mass and Quality of Life in Patients with Unresectable Pancreatic Cancer (HY-PANC): Study Protocol for a Randomized Controlled Trial.Current protocols · 2026Article
- The association of thigh myosteatosis with lower cognitive function in older cancer survivors.GeroScience · 2026Article
- Frailty in older patients with cancer in Vietnam.BMC geriatrics · 2026Observational
- Prevalence of Malnutrition, Frailty, and Cachexia Across Different Cancer Subtypes: Distribution by Age (<65 and ≥65).Journal of clinical medicine · 2026Article
- Sarcopenia in breast cancer: prognostic values and emerging therapeutic strategies.Frontiers in surgery · 2026Review
- Sarcopenia and Cachexia in Older Patients with Cancer: Pathophysiology, Diagnosis, Impact on Outcomes, and Management Strategies.Drugs & aging · 2025Review
- UQCR10 and TNNT1: novel biomarkers for sarcopenia identified through integrated transcriptomic analysis and machine learning.European journal of medical research · 2025Article
- The influence of sarcopenia on health-related quality of life among older patients with gastrointestinal cancer: an assessment using the SarQoLAging clinical and experimental research · 2025Article
- Prehabilitation for muscle wasting in cancer: do definitions matter?Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Review
- Effect of Cancer Cachexia on the Efficacy and Treatment Delivery of Chemotherapy in Older Patients With Advanced Small Cell Lung Cancer.Thoracic cancer · 2025Article
- Possible Use of Body Surface Area Value for Estimating Skeletal Muscle Mass in Chronic Liver Disease.Diagnostics (Basel, Switzerland) · 2025Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Cancer cachexia is a syndrome characterized by weight loss with accompanying loss of muscle and/or fat mass and leads to impaired patient function and physical performance and is associated with a poor prognosis. It is prevalent in older adults with cancer; age-associated physiologic muscle wasting and weakness, also known as sarcopenia, can compound deficits associated with cancer cachexia in older adults and makes studying this condition more complex in this population. Multiple measurement options are available to assess the older patient with cancer and cachexia and/or sarcopenia including anthropometric measures, imaging modalities such as Dual X-ray absorptiometry (DEXA) and Computed Tomography (CT), muscular strength and physical performance testing, and patient-reported outcomes (PROs). A geriatric assessment (GA) is a useful tool when studying the older patient with cachexia given its comprehensive ability to capture aging-sensitive PROs. Interventions focused on nutrition and increasing physical activity may improve outcomes in older adults with cachexia. Efforts to develop targeted pharmacologic therapies with cachexia have not been successful thus far. Formal treatment guidelines, an updated consensus definition for cancer cachexia and the development of a widely adapted assessment tool, much like the GA utilized in geriatric oncology, could help advance the field of cancer cachexia over the next decade.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.