ArticlePsychological medicine2021
Reduced limbic microstructural integrity in functional neurological disorder.
Article in Psychological medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Autonomic, Endocrine, and Inflammation Profiles in Functional Neurological Disorder: A Systematic Review and Meta-Analysis.The Journal of neuropsychiatry and clinical neurosciences · 2022Pooled it
- Imaging biomarkers in functional neurological disorders.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Rewiring brain structural and functional disconnection with acupuncture in rat model of vascular cognitive impairment and dementia.Biological research · 2026Article
- Ultra-high field brain MRI for functional neurological disorder: opportunities and challenges.NeuroImage. Clinical · 2026Review
- Functional Movement Disorder: Evolving Mechanisms, Diagnostic Precision, and Personalized Multidisciplinary Care.Movement disorders clinical practice · 2025Review
- Machine learning classification of functional neurological disorder using structural brain MRI features.Journal of neurology, neurosurgery, and psychiatry · 2025Article
- Predictive Processing and the Pathophysiology of Functional Neurological Disorder.Current topics in behavioral neurosciences · 2025Review
- Revisiting motor inhibition in individuals with functional paralysis and spinal cord injury.Brain communications · 2025Article
- Stress convulsions in rodents: within a weight-of-evidence framework for human seizure risk.Frontiers in toxicology · 2025Article
- Functional Neurologic Disorder,Neurology · 2024Article
- Biomarkers and Rehabilitation for Functional Neurological Disorder.Journal of personalized medicine · 2024Review
- Long COVID Is Not a Functional Neurologic Disorder.Journal of personalized medicine · 2024Review
- Microstructural Differences of the Cerebellum-Thalamus-Basal Ganglia-Limbic Cortex in Patients with Somatic Symptom Disorders: a Diffusion Kurtosis Imaging Study.Cerebellum (London, England) · 2023Article
- White Matter Structural Connectivity and Its Impact on Psychogenic Non-Epileptic Seizures: An Evidence-Based Review.Neuropsychiatric disease and treatment · 2023Review
- Updates in Functional Movement Disorders: from Pathophysiology to Treatment Advances.Current neurology and neuroscience reports · 2022Review
- Abnormal White Matter Microstructure in the Limbic System Is Associated With Tuberous Sclerosis Complex-Associated Neuropsychiatric Disorders.Frontiers in neurology · 2022Article
- Individual differences in interoceptive accuracy and prediction error in motor functional neurological disorders: A DTI study.Human brain mapping · 2021Article
- Functional neurological disorders in patients undergoing spinal surgery: illustrative case.Journal of neurosurgery. Case lessons · 2021Article
- Neuroimaging in Functional Neurological Disorder: State of the Field and Research Agenda.NeuroImage. Clinical · 2021Review
- White matter and neurite morphology differ in psychogenic nonepileptic seizures.Annals of clinical and translational neurology · 2020Article
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5 authors.
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Abstract
backgroundFunctional neurological disorder (FND) is a condition at the intersection of neurology and psychiatry. Individuals with FND exhibit corticolimbic abnormalities, yet little is known about the role of white matter tracts in the pathophysiology of FND. This study characterized between-group differences in microstructural integrity, and correlated fiber bundle integrity with symptom severity, physical disability, and illness duration.
methodsA diffusion tensor imaging (DTI) study was performed in 32 patients with mixed FND compared to 36 healthy controls. Diffusion-weighted magnetic resonance images were collected along with patient-reported symptom severity, physical disability (Short Form Health Survey-36), and illness duration data. Weighted-degree and link-level graph theory and probabilistic tractography analyses characterized fractional anisotropy (FA) values across cortico-subcortical connections. Results were corrected for multiple comparisons.
resultsCompared to controls, FND patients showed reduced FA in the stria terminalis/fornix, medial forebrain bundle, extreme capsule, uncinate fasciculus, cingulum bundle, corpus callosum, and striatal-postcentral gyrus projections. Except for the stria terminalis/fornix, these differences remained significant adjusting for depression and anxiety. In within-group analyses, physical disability inversely correlated with stria terminalis/fornix and medial forebrain bundle FA values; illness duration negatively correlated with stria terminalis/fornix white matter integrity. A FND symptom severity composite score did not correlate with FA in patients.
conclusionsIn this first DTI study of mixed FND, microstructural differences were observed in limbic and associative tracts implicated in salience, defensive behaviors, and emotion regulation. These findings advance our understanding of neurocircuit pathways in the pathophysiology of FND.
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