ArticleDiabetes & metabolism journal2020
Incidence and Risk Factors for Dementia in Type 2 Diabetes Mellitus: A Nationwide Population-Based Study in Korea.
Article in Diabetes & metabolism journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 5 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Diabetic Retinopathy and Cognitive Dysfunction in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Epidemiological Associations and Clinical Implications.Journal of diabetes research · 2026Pooled it
- Diabetic retinopathy and the risk of all-cause dementia, Alzheimer's disease, and vascular dementia: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Associations of glycaemia-related risk factors with dementia and cognitive decline in individuals with type 2 diabetes: A systematic review and meta-analysis.Diabetic medicine : a journal of the British Diabetic Association · 2025Pooled it
- Diabetic retinopathy and cognitive dysfunction: a systematic review and meta-analysis.Acta diabetologica · 2022Pooled it
- Association Between Diabetic Retinopathy and Cognitive Impairment: A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2021Pooled it
- Cardiometabolic measures and cognition in early menopause - Analysis of baseline data from a randomized controlled trial.Maturitas · 2022Trial
- Dementia Risk in Type 1 and 2 Diabetes: A Nationwide Population-Based Comparison.Diabetes, obesity & metabolism · 2026Article
- Review
- Association between multimorbidity and young-onset dementia: a prospective study.BMC public health · 2025Article
- Job Loss and Early-onset Dementia Risk in Middle-aged Adults: A Longitudinal Study.Safety and health at work · 2025Article
- The influence of diabetic retinopathy on the risk of dementia: A nationwide cohort study.Scientific reports · 2025Article
- New-generation antidiabetic medications and dementia risk in older adults with type 2 diabetes: A retrospective cohort study.The journal of prevention of Alzheimer's disease · 2025Article
- Diabetes status, duration and risk of dementia in patients with myocardial infarction.Diabetology & metabolic syndrome · 2025Article
- Longitudinal trends in dementia prevalence among individuals with type 2 diabetes in Taiwan (2009-2022).Journal of diabetes investigation · 2025Article
- Oral diadochokinesis performance correlates with mild cognitive impairment: a cross-sectional study.BMC oral health · 2025Article
- Effect of Social Activity on All-Cause Dementia Among South Korean Elders: A Retrospective Cohort Study.Health science reports · 2025Article
- Development of machine learning models for prediction of current and future dementia.PloS one · 2025Article
- Association of amyloid and cardiovascular risk with cognition: Findings from KBASE.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Machine Learning-Based Prediction of Neurodegenerative Disease in Patients With Type 2 Diabetes by Derivation and Validation in 2 Independent Korean Cohorts: Model Development and Validation Study.Journal of medical Internet research · 2024Article
- Type-2 Diabetes Alters Hippocampal Neural Oscillations and Disrupts Synchrony between the Hippocampus and Cortex.Aging and disease · 2024Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundDiabetes mellitus is associated with an increased risk of dementia. We aimed to comprehensively analyze the incidence and risk factors for dementia and young-onset dementia (YOD) in diabetic patients in Korea using the National Health Insurance Service data.
methodsBetween January 1, 2009 and December 31, 2012, a total of 1,917,702 participants with diabetes were included and followed until the date of dementia diagnosis or until December 31, 2015. We evaluated the incidence and risk factors for all dementia, Alzheimer's disease (AD), and vascular dementia (VaD) by Cox proportional hazards analyses. We also compared the impact of risk factors on the occurrence of YOD and late-onset dementia (LOD).
resultsDuring an average of 5.1 years of follow-up, the incidence of all types of dementia, AD, or VaD was 9.5, 6.8, and 1.3/1,000 person-years, respectively, in participants with diabetes. YOD comprised 4.8% of all dementia occurrence, and the ratio of AD/VaD was 2.1 for YOD compared with 5.5 for LOD. Current smokers and subjects with lower income, plasma glucose levels, body mass index (BMI), and subjects with hypertension, dyslipidemia, vascular complications, depression, and insulin treatment developed dementia more frequently. Vascular risk factors such as smoking, hypertension, and previous cardiovascular diseases were more strongly associated with the development of VaD than AD. Low BMI and a history of stroke or depression had a stronger influence on the development of YOD than LOD.
conclusionThe optimal management of modifiable risk factors may be important for preventing dementia in subjects with diabetes mellitus.
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