Evidence map›Paper›PMID 31769017›Full record

ReviewFEBS letters2019

Genomic foundations of evolution and ocular pathogenesis in human adenovirus species D.

Ashrafali Mohamed Ismail, Xiaohong Zhou, David W Dyer, Donald Seto, Jaya Rajaiya, James Chodosh

Open access · greenAbstract readReview
In one paragraph

Review in FEBS letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 45 citations in OpenAlex.

  1. Trial
  2. Adenoviral E3/49K: CD45-targeted immune evasion and therapeutic potential.Frontiers in cellular and infection microbiology · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Viral Conjunctivitis.Viruses · 2023
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Human Adenovirus Associated Hepatic Injury.Frontiers in public health · 2022
    Review
  16. Study on the Anti-Adenovirus Mechanism ofFrontiers in cellular and infection microbiology · 2022
    Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ashrafali Mohamed IsmailMassachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8694-7235
Xiaohong ZhouMassachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
David W DyerDepartment of Microbiology and Immunology, University of Oklahoma Health Sciences Center, OK, USA.
Donald SetoBioinformatics and Computational Biology Program, School of Systems Biology, George Mason University, Manassas, VA, USA.
Jaya RajaiyaMassachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
James ChodoshMassachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-7463-1599
Massachusetts Eye and Ear Infirmary · USGeorge Mason University · USUniversity of Oklahoma Health Sciences Center · US

Funding

Proteomics CoreP20GM103447 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Mark L Lang · 2012 to 2026
$60.2M
P30 Core Grant for Vision ResearchP30EY014104 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Janey L Wiggs · 2002 to 2026
$15.1M
Immunopathogenesis of Adenovirus KeratitisR01EY013124 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI James Chodosh, Jaya Rajaiya · 2001 to 2026
$10.8M
Novel Mechanisms in Adenoviral Ocular PathogenesisR01EY021558 · NEI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI James Chodosh, Jaya Rajaiya · 2011 to 2026
$7.1M
Genetics of Ocular AdenovirusesR03EY015222 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CHODOSH, JAMES · 2004 to 2006
$436k
Massachusetts Lions Eye Research FundNEI NIH HHS P30 EY014104NEI NIH HHS R01 EY013124NEI NIH HHS R01 EY021558NEI NIH HHS R03 EY015222NIGMS NIH HHS P20 GM103447Research to Prevent Blindness, Inc., New York, NY
6 · The paper itself

Abstract

Human adenovirus commonly causes infections of respiratory, gastrointestinal, genitourinary, and ocular surface mucosae. Although most adenovirus eye infections are mild and self-limited, specific viruses within human adenovirus species D are associated with epidemic keratoconjunctivitis (EKC), a severe and highly contagious ocular surface infection, which can lead to chronic and/or recurrent, visually disabling keratitis. In this review, we discuss the links between adenovirus ontogeny, genomics, immune responses, and corneal pathogenesis, for those viruses that cause EKC.

Indexed as

Biological EvolutionAdenoviruses, HumanAnimalsConjunctivaCorneaDisease Models, AnimalEye ProteinsGene Expression RegulationGenomicsHost-Pathogen InteractionsHumansImmunity, InnateKeratitisKeratoconjunctivitisPhylogenyViral ProteinsEye ProteinsViral Proteinsconjunctivitisepidemic keratoconjunctivitisgenomicshomologous recombinationhuman adenovirusinflammationocular infectionpink eyetropismvirus evolution

Identifiers

PMID31769017
PMCPMC7185199
OpenAlexW2990317570

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.