Evidence map›Paper›PMID 31768871›Full record

ArticleChinese journal of integrative medicine2020

Antioxidant and Antiapoptotic Polyphenols from Green Tea Extract Ameliorate CCl

Jian-Xin Diao, Jin-Ying Ou, Huan Dai, Hai-Ye Li, Wei Huang, He-Yu Hua, Ting Xie, Ming Wang, Yun-Gao Yang

Abstract read
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In one paragraph

Article in Chinese journal of integrative medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Protective Effects ofJournal of toxicology · 2026
    Article
  2. Improvement effect of Biluochun tea active extract on CClFood science and biotechnology · 2025
    Article
  3. Impact of Traditional Chinese Medicine Antioxidants on Oxidative Stress and Drug-Induced Liver Injury: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2024
    Review
  4. Review
  5. Toxics · 2023
    Article
  6. Protective Effect ofNutrients · 2021
    Article
  7. Article
  8. Article
  9. The Protective Impact ofFrontiers in veterinary science · 2021
    Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jian-Xin DiaoSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
Jin-Ying OuSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
Huan DaiDepartment of Internal Medicine, Yongxing County People's Hospital, Chengzhou, 423000, Hunan Province, China.
Hai-Ye LiSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
Wei HuangSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
He-Yu HuaSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
Ting XieSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
Ming WangDepartment of Traditional Chinese Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, 510515, China.
Yun-Gao YangSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China. m13560474923@163.com.
Southern Medical University · CNZhujiang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the phenolic composition, antioxidant properties, and hepatoprotective mechanisms of polyphenols from green tea extract (GTP) in carbon tetrachloride (CCl

methodsHigh-performance liquid chromatography was used to analyze the chemical composition of the extract. Antioxidant activity of GTP was assessed by O

resultsGTP contained 98.56 µg gallic acid equivalents per milligram extract total polyphenols, including epicatechingallate, epigallocatechin gallate, epicatechin, and epigallocatechin. Compared with the model group, low-, medium-, or high doses GTP significantly decreased serum levels of alanine aminotransferase and aspartate transaminase (P<0.01). Histopathological observation confirmed that pretreatment of GTP prevented swelling and necrosis in CCl

conclusionGTP achieves hepatoprotective effects by improving hepatic antioxidant status and preventing cell apoptosis through caspase-3-dependent signaling pathways.

Indexed as

TeaAnimalsAntioxidantsApoptosisBiomarkersCarbon TetrachlorideCaspase 3Chemical and Drug Induced Liver InjuryChinaDisease Models, AnimalMaleMicePlant ExtractsPolyphenolsAntioxidantsBiomarkersCarbon TetrachlorideCasp3 protein, mouseCaspase 3Plant ExtractsPolyphenolsTeaacute liver injuryanti-apoptosisanti-oxidantcarbon tetrachloridegreen teapolyphenol

Identifiers

PMID31768871
OpenAlexW2991115291

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.