Evidence map›Paper›PMID 31768797›Full record

ArticleMagma (New York, N.Y.)2020

Consensus-based technical recommendations for clinical translation of renal BOLD MRI.

Octavia Bane, Iosif A Mendichovszky, Bastien Milani, Ilona A Dekkers, Jean-Francois Deux, Per Eckerbom, Nicolas Grenier, Michael E Hall, Tsutomu Inoue, Christoffer Laustsen and 18 more

Abstract readConsensus Statement
In one paragraph

Article in Magma (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Simultaneous TMagnetic resonance in medicine · 2026
    Article
  4. Article
  5. Article
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  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Magnetic resonance imaging of renal oxygenation.Nature reviews. Nephrology · 2025
    Review
  16. Review
  17. Article
  18. Review
  19. Ex Vivo Simultaneous HJournal of imaging · 2024
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Octavia BaneBioMedical Engineering and Imaging Institute and Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-1315-5848
Iosif A MendichovszkyDepartment of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, UK.
Bastien MilaniCenter for BioMedical Imaging, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Ilona A DekkersDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Jean-Francois DeuxDepartment of Radiology, Groupe Hospitalier Henri Mondor, Créteil, France.
Per EckerbomDepartment of Radiology, Institution for Surgical Sciences, Uppsala University, Uppsala, Sweden.
Nicolas GrenierDepartment of Radiology, Université de Bordeaux, CHU de Bordeaux, Bordeaux, France.
Michael E HallDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Tsutomu InoueDepartment of Nephrology, Faculty of Medicine, Saitama Medical University, Saitama, Japan.
Christoffer LaustsenThe MR Research Center Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Lilach O LermanDivision of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Chunlei LiuElectrical Engineering and Computer Science, and Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA.
Glen MorrellDepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, USA.
Michael PedersenDepartment of Clinical Medicine-Comparative Medicine Lab, Aarhus University Hospital, Aarhus, Denmark.
Menno PruijmNephrology and Hypertension Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Elizabeth A SadowskiDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Erdmann SeeligerInstitute of Physiology, Charité-University Medicine Berlin, Berlin, Germany.
Kanishka SharmaImaging Biomarkers Group, Department of Biomedical Imaging Sciences, University of Leeds, Leeds, UK.
Harriet ThoenyDepartment of Radiology, Hôpital Cantonal Fribourgois, University of Fribourg, Fribourg, Switzerland.
Peter VermathenDepartments for BioMedical Research and Radiology, Inselspital, Universitaetspital Bern, Bern, Switzerland.
Zhen J WangDepartment of Radiology and Biomedical Imaging, University of California San Francisco Medical Center, San Francisco, CA, USA.
Zbigniew SerafinDepartment of Radiology, Nicolaus Copernicus University, Collegium Medicum, Bydgoszcz, Poland.
Jeff L ZhangAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Susan T FrancisSir Peter Mansfield Centre, University of Notthingham, Notthingham, UK.
Steven SourbronImaging Biomarkers Group, Department of Biomedical Imaging Sciences, University of Leeds, Leeds, UK.
Andreas PohlmannBerlin Ultrahigh Field Facility, Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Sean B FainDepartments of Biomedical Engineering, Radiology, and Medical Physics, University of Wisconsin, Madison, WI, USA.
Pottumarthi V PrasadDepartment of Radiology, Center for Advanced Imaging, NorthShore University Health System, Evanston, IL, USA. pprasad@northshore.org.

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI MASON, SARAH · 2016 to 2025
$38.2M
Longitudinal changes in the intra-renal oxygenation by BOLD MRI in patients withR01DK093793 · NIDDK · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI PRASAD, POTTUMARTHI V · 2012 to 2016
$2.3M
Renal hypoxia in the development of glomerular fibrosisR01DK109349 · NIDDK · UNIVERSITY OF UTAH · PI AY, ILKNUR · 2017 to 2020
$1.7M
Renal Sinus Fat, Hypertension, and Altered Kidney FunctionK08DK099415 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, MICHAEL EDWARD · 2015 to 2019
$791k
Intrarenal Oxygenation: An Early Marker for Risk of Developing AKIR01DK106557 · NIDDK · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI PRASAD, POTTUMARTHI V · 2016 to 2018
$717k
Quantification of Renal Perfusion, Diffusion and Hypoxia Using Advanced MRI Methods for Assessment of Renal Transplant DysfunctionF32DK109591 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BANE, OCTAVIA · 2016 to 2018
$126k
Deutsche Forschungsgemeinschaft Collaborative Research Centre SFB 1365 RenoprotectionEuropean Cooperation in Science and Technology Action CA 16103Innovative Medicines Initiative 115974Medical Research Council MR/R02264X/1NIDDK NIH HHS 1F32DK109591NIDDK NIH HHS F32 DK109591NIDDK NIH HHS K08 DK099415NIDDK NIH HHS R01 DK093793NIDDK NIH HHS R01 DK106557NIDDK NIH HHS R01 DK109349NIGMS NIH HHS U54 GM115428Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 320030-169191Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung NIZCOZO_177140/1
6 · The paper itself

Abstract

Harmonization of acquisition and analysis protocols is an important step in the validation of BOLD MRI as a renal biomarker. This harmonization initiative provides technical recommendations based on a consensus report with the aim to move towards standardized protocols that facilitate clinical translation and comparison of data across sites. We used a recently published systematic review paper, which included a detailed summary of renal BOLD MRI technical parameters and areas of investigation in its supplementary material, as the starting point in developing the survey questionnaires for seeking consensus. Survey data were collected via the Delphi consensus process from 24 researchers on renal BOLD MRI exam preparation, data acquisition, data analysis, and interpretation. Consensus was defined as ≥ 75% unanimity in response. Among 31 survey questions, 14 achieved consensus resolution, 12 showed clear respondent preference (65-74% agreement), and 5 showed equal (50/50%) split in opinion among respondents. Recommendations for subject preparation, data acquisition, processing and reporting are given based on the survey results and review of the literature. These technical recommendations are aimed towards increased inter-site harmonization, a first step towards standardization of renal BOLD MRI protocols across sites. We expect this to be an iterative process updated dynamically based on progress in the field.

Indexed as

KidneyMagnetic Resonance ImagingAnimalsBiomarkersConsensusDelphi TechniqueHumansReproducibility of ResultsSignal-To-Noise RatioSurveys and QuestionnairesSystematic Reviews as TopicTranslational Research, BiomedicalBiomarkersBiomarkersBOLD MRIConsensusImagingKidneyStandardization

Identifiers

PMID31768797
PMCPMC7021747

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.