ArticleGenes & genomics2020
High expression of keratin 6C is associated with poor prognosis and accelerates cancer proliferation and migration by modulating epithelial-mesenchymal transition in lung adenocarcinoma.
Article in Genes & genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Identification of potential salivary biomarker panels for oral squamous cell carcinoma.Scientific reports · 2021Trial
- MetaPaCS: A Novel Meta-Learning Framework for Pancreatic Cancer Subtype Identification.bioRxiv : the preprint server for biology · 2026Article
- A deep learning model for multiclass lung cancer classification using multimodal data fusion.Discover oncology · 2025Article
- Whole exome sequencing identified mutations of forkhead box I 1 (FOXI1), keratin 6 C (KRT6C) and gap junction protein delta 2 (GJD2) in a low-grade oncocytic tumor of the kidney: a case report.Diagnostic pathology · 2025Article
- Assessment of Concentration KRT6 Proteins in Tumor and Matching Surgical Margin from Patients with Head and Neck Squamous Cell Carcinoma.International journal of molecular sciences · 2024Article
- Down-regulation of KLRB1 is associated with increased cell growth, metastasis, poor prognosis, as well as a dysfunctional immune microenvironment in LUAD.Scientific reports · 2024Article
- A Kaleidoscope of Keratin Gene Expression and the Mosaic of Its Regulatory Mechanisms.International journal of molecular sciences · 2023Review
- Role of TRPV1 ion channel in cervical squamous cell carcinoma genesis.Frontiers in molecular biosciences · 2022Article
- Transcript levels of keratin 1/5/6/14/15/16/17 as potential prognostic indicators in melanoma patients.Scientific reports · 2021Article
- Low Expression of Keratin17 is Related to Poor Prognosis in Bladder Cancer.OncoTargets and therapy · 2021Article
- Article
- The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget's disease.Cell research · 2020Article
- Construction and evaluation of an aging-associated genes-based model for pancreatic adenocarcinoma prognosis and therapies.International journal of immunopathology and pharmacologyArticle
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Authors and funding
5 authors.
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Abstract
backgroundLung adenocarcinoma (LUAD) is a more frequent subtype of lung cancer and most cases are discovered in the late stages. The proliferation and metastasis of LUAD are pivotal for disease progression. Despite unremitting deeper understanding of LUAD biology, the mechanisms involved in the proliferation and metastasis of LUAD remain unclear. The objective of our article was to inquiry the expression and the function of keratin 6C (KRT6C) in LUAD cells.
methodsFirst, the expression level and prognostic value of KRT6C in LUAD tissues were analyzed on the basis of the data acquired from TCGA database. Through qRT-PCR, the expression level of KRT6C on LUAD cell lines (A549, H1299, PC-9) and human normal lung cell line MRC-5 was tested. After that, CCK8 and colony formation assays was utilized to detect cell proliferation. In addition, to explore the influence of KRT6C on LUAD migration and invasion ability, scratch wound healing and transwell assays were utilized. Through western blotting, the protein expression levels of KRT6C, PCNA, E-cadherin, N-cadherin, Snail and Vimentin were detected.
resultsThe outcomes revealed that KRT6C was highly expressed in LUAD tissues and cell lines. Besides, elevated level of KRT6C was related to worse prognosis in LUAD patients. Ablation of KRT6C restrained proliferation, migration and invasion of A549 cells. KRT6C deficiency augmented the expression of E-cadherin as well as reduced the expression of N-cadherin, Snail and Vimentin.
conclusionAbove all, these consequences indicated that depletion of KRT6C suppressed A549 cell proliferation, migration and invasion, which might be achieved by regulating EMT. In general, KRT6C is identified as a potential therapeutic target for LUAD.
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