Evidence map›Paper›PMID 31768722›Full record

ArticleJournal of bioenergetics and biomembranes2019

Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury.

Liangtong Li, Tongtong Liu, Li Liu, Shaochun Li, Zhe Zhang, Ruisha Zhang, Yujuan Zhou, Fulin Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of bioenergetics and biomembranes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 51 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Research progress in clinical utilization of HFrontiers in pharmacology · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Hydrogen Protection Boosts the Bioactivity ofAntioxidants (Basel, Switzerland) · 2023
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Toxicology reports · 2021
    Article
  16. Review
  17. Article
  18. Article
  19. [Hydrogen water alleviates paraquat-induced lung fibroblast injuryNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Liangtong LiMedical College, Hebei University, Baoding, 071000, China.
Tongtong LiuAffiliated Hospital of Hebei University, Baoding, 071000, China.
Li LiuMedical College, Hebei University, Baoding, 071000, China.
Shaochun LiMedical College, Hebei University, Baoding, 071000, China.
Zhe ZhangMedical College, Hebei University, Baoding, 071000, China.
Ruisha ZhangMedical College, Hebei University, Baoding, 071000, China.
Yujuan ZhouMedical College, Hebei University, Baoding, 071000, China. zyj@hbu.edu.cn.
Fulin LiuAffiliated Hospital of Hebei University, Baoding, 071000, China. lful666@sina.com.
Hebei University · CNAffiliated Hospital of Hebei University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effects of hydrogen-rich water on oxidative stress via the Nrf2/ARE signaling pathway were studied in rats with myocardial ischemia-reperfusion injury (MIRI). Sixty rats were randomly divided into a hydrogen-rich water group and a control group, with 30 rats in each group. The two groups were randomly divided into three groups: pre-ischemic period, ischemic period and reperfusion period. After the heart was removed, it was fixed in a Langendorff device and perfused with an oxygen-balanced 37 °C perfusate. The control group was perfused with Kreb's-Ringers (K-R) solution, and the hydrogen-rich water group was perfused with K-R solution + hydrogen-rich water. The levels of mRNA and protein of Nrf2, NQO1, HO-1 and SOD-1 in cardiomyocytes were detected by RT-qPCR, immunohistochemistry (IHC) and Western blot analysis. SOD activity and MDA content were determined. Hydrogen-rich water increased the activation of the Nrf2/ARE signaling pathway, and the levels of mRNA and protein Nrf2, NQO1, HO-1 and SOD-1 were significantly increased (P < 0.05) in the ischemia-reperfusion period compared with the ischemic period. In the control group, the levels of mRNA and protein of Nrf2, NQO1, HO-1 and SOD-1 were significantly decreased (P < 0.05) in the ischemia-reperfusion period compared with the ischemic period. Compared with the ischemic period, the ischemia-reperfusion phase showed significantly increased SOD activity and significantly decreased MDA content in the hydrogen-rich water group, while SOD activity was significantly decreased, and MDA content was significantly increased in the control group (P < 0.05). Hydrogen-rich water can activate the Nrf2/ARE signaling pathway, alleviate ischemia-reperfusion injury in isolated rat hearts and reduce the oxidative stress level of myocardial tissue.

Indexed as

AnimalsDisease Models, AnimalHumansHydrogenMaleMyocardial Reperfusion InjuryNF-E2-Related Factor 2RatsRats, WistarSignal TransductionWaterHydrogenNF-E2-Related Factor 2WaterHydrogen-rich waterMDAMyocardial ischemia-reperfusion injuryNrf2/ARE signaling pathwayOxidative stressSOD

Identifiers

PMID31768722
OpenAlexW3002853676

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.