Evidence map›Paper›PMID 31768588›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2020

Parenthood and risk of hip fracture: a 10-year follow-up prospective study of middle-aged women and men in China.

K Peng, P Yao, L Yang, C Kartsonaki, D Bennett, M Tian, Y Guo, Z Bian, Y Chen, Z Chen and 3 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 4 countries.

K PengSchool of Public Health, The University of Sydney, Sydney, Australia.
P YaoClinical Trial Service Unit and Epidemiological Studies Unit, Big Data Institute, University of Oxford, Old Road Campus, Oxford, OX3 7LF, UK.
L YangClinical Trial Service Unit and Epidemiological Studies Unit, Big Data Institute, University of Oxford, Old Road Campus, Oxford, OX3 7LF, UK.
C KartsonakiClinical Trial Service Unit and Epidemiological Studies Unit, Big Data Institute, University of Oxford, Old Road Campus, Oxford, OX3 7LF, UK.
D BennettClinical Trial Service Unit and Epidemiological Studies Unit, Big Data Institute, University of Oxford, Old Road Campus, Oxford, OX3 7LF, UK.
M TianThe George Institute for Global Health, UNSW, Sydney, Australia.
Y GuoChinese Academy of Medical Sciences, Beijing, China.
Z BianChinese Academy of Medical Sciences, Beijing, China.
Y ChenClinical Trial Service Unit and Epidemiological Studies Unit, Big Data Institute, University of Oxford, Old Road Campus, Oxford, OX3 7LF, UK.
Z ChenClinical Trial Service Unit and Epidemiological Studies Unit, Big Data Institute, University of Oxford, Old Road Campus, Oxford, OX3 7LF, UK.
M WoodwardThe George Institute for Global Health, UNSW, Sydney, Australia.
R IversSchool of Public Health, The University of Sydney, Sydney, Australia.
R ClarkeClinical Trial Service Unit and Epidemiological Studies Unit, Big Data Institute, University of Oxford, Old Road Campus, Oxford, OX3 7LF, UK. robert.clarke@ndph.ox.ac.uk.ORCID http://orcid.org/0000-0002-9802-8241
University of Oxford · GBChinese Academy of Medical Sciences & Peking Union Medical College · CNThe University of Sydney · AUJohns Hopkins University · USPeking University · CN

Funding

Cancer Research UK 29186Medical Research Council MC_U137686851Medical Research Council MC_UU_00017/1Medical Research Council MC_UU_12026/2Wellcome Trust 104085/Z/14/ZWellcome Trust 202922/Z/16/ZWellcome Trust 212946/Z/18/Z
6 · The paper itself

Abstract

This prospective study of Chinese adults demonstrated an inverse J-shaped association of number of children with risk of hip fracture in both men and postmenopausal women aged 50 years or older. Women with 2 or 3 children and men with 4 children had the lowest risk of hip fracture.

introductionWomen have higher absolute risks of fracture than men, which is believed to reflect differences in oestrogen exposure. The aim of this study was to compare the associations of number of children with risk of hip fracture between men and women aged over 50 years.

methodsThe China Kadoorie Biobank (CKB) recruited 133,399 women and 110,296 men, aged 50 years or older between 2004 and 2008. During 10-year follow-up, 2068 participants (1394 women and 674 men) suffered a hip fracture. Cox regression analysis was used to estimate sex-specific adjusted hazard ratios (HRs) and 95% CI for incident hip fracture.

resultsOver 98% of both subsets of men and women aged 50 or older reported having children. Women who had 2 or 3 children had the lowest risks of hip fracture compared with other groups. Compared with nulliparous women, the adjusted HR for hip fracture were 0.89 (95% CI; 0.72, 1.10) for 1 child, 0.79 (0.70, 0.90) for 2 children, 0.79 (0.72, 0.87) for 3 children, 0.81 (0.72, 0.91) for 4 children, and 0.95 (0.83, 1.10) for those with 5 or more children. The associations of number of children with hip fracture were broadly consistent in men of a similar age.

conclusionsThe concordant effects of the number of children with risk of hip fracture between men and women suggest that the lower risks in multiparous women are not due to differences in oestrogen exposure or other biological effects, but may reflect residual confounding by socioeconomic or lifestyle factors.

Indexed as

Hip FracturesAdultAgedChildChinaFemaleFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesRisk FactorsHip fractureNumber of childrenParenthoodSex

Identifiers

PMID31768588
PMCPMC7075818
OpenAlexW2981615323

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.