ArticleStructural dynamics (Melville, N.Y.)2019
The Integrated Resource for Reproducibility in Macromolecular Crystallography: Experiences of the first four years.
Article in Structural dynamics (Melville, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Protein Data Bank Japan: Computational Resources for Analysis of Protein Structures.Journal of molecular biology · 2025Article
- How can we make sound replication decisions?Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Exploring Subsite Selectivity withinJournal of medicinal chemistry · 2024Article
- Identification of and Structural Insights into Hit Compounds TargetingACS infectious diseases · 2023Article
- Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts.Nature communications · 2023Article
- Bacterial structural genomics target enabled by a recently discovered potent fungal acetyl-CoA synthetase inhibitor.Acta crystallographica. Section F, Structural biology communications · 2023Article
- Structural biology and public health response to biomedical threats.Structural dynamics (Melville, N.Y.) · 2023Article
- Article
- Serial femtosecond crystallography.Nature reviews. Methods primers · 2022Article
- Article
- Article
- Optimal structure determination from sub-optimal diffraction data.Protein science : a publication of the Protein Society · 2022Article
- Detecting anomalies in X-ray diffraction images using convolutional neural networks.Expert systems with applications · 2021Article
- Article
- Validation of the Crystallography Open Database using the Crystallographic Information Framework.Journal of applied crystallography · 2021Article
- Sharing biological data: why, when, and how.FEBS letters · 2021Article
- Crystal structure of timothy grass allergen Phl p 12.0101 reveals an unusual profilin dimer.Acta biochimica Polonica · 2021Article
- Synchrotron Radiation as a Tool for Macromolecular X-Ray Crystallography: a XXI Century Perspective.Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms · 2021Article
- A study on the structure, mechanism, and biochemistry of kanamycin B dioxygenase (KanJ)-an enzyme with a broad range of substrates.The FEBS journal · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
It has been increasingly recognized that preservation and public accessibility of primary experimental data are cornerstones necessary for the reproducibility of empirical sciences. In the field of molecular crystallography, many journals now recommend that authors of manuscripts presenting a new crystal structure should deposit their primary experimental data (X-ray diffraction images) to one of the dedicated resources created in recent years. Here, we describe our experiences developing the Integrated Resource for Reproducibility in Molecular Crystallography (IRRMC) and describe several examples of a crucial role that diffraction data can play in improving previously determined protein structures. In its first four years, several hundred crystallographers have deposited data from over 5200 diffraction experiments performed at over 60 different synchrotron beamlines or home sources all over the world. In addition to improving the resource and curating submitted data, we have been building a pipeline for extraction or, in some cases, reconstruction of the metadata necessary for seamless automated processing. Preliminary analysis indicates that about 95% of the archived data can be automatically reprocessed. A high rate of reprocessing success shows the feasibility of using the automated metadata extraction and automated processing as a validation step for the deposition of raw diffraction images. The IRRMC is guided by the Findable, Accessible, Interoperable, and Reusable data management principles.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.