ArticleMolecular neuropsychiatry2019
Research Domain Criteria: Strengths, Weaknesses, and Potential Alternatives for Future Psychiatric Research.
Article in Molecular neuropsychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Rethinking the psychosis spectrum: A meta-analysis unveils a nonlinear discontinuity in verbal learning deficits between at-risk conditions and psychotic disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Towards a Multidimensional Model of Neurocognitive Disorders (MOND Model): Integrating Evidence from a Critical Review into a Model for Future Research.Journal of personalized medicine · 2026Review
- A Framework for Advancing Mechanistic Neurobehavioral Biomarkers in Psychiatry.Biological psychiatry · 2026Review
- Addiction spectrum disorder: a conceptual framework for comprehensive understanding of addictive disorders.Frontiers in psychology · 2026Article
- Cooking for disability: a pilot study on nutritional interventions for mental health support in adults with autism spectrum disorder.Frontiers in psychiatry · 2025Article
- The Limbic System in Co-Occurring Substance Use and Anxiety Disorders: A Narrative Review Using the RDoC Framework.Brain sciences · 2024Review
- Translational In Vivo Assays in Behavioral Biology.Annual review of pharmacology and toxicology · 2024Review
- RDoC Framework Through the Lens of Predictive Processing: Focusing on Cognitive Systems Domain.Computational psychiatry (Cambridge, Mass.) · 2024Review
- Do We Need a Novel Framework for Classifying Psychopathology? A Discussion Paper.Clinical psychology in Europe · 2023Review
- Improving Translational Relevance in Preclinical Psychopharmacology (iTRIPP).Journal of psychopharmacology (Oxford, England) · 2023Article
- Major depressive disorder.Nature reviews. Disease primers · 2023Review
- The future of diagnosis in clinical neurosciences: Comparing multiple sclerosis and schizophrenia.European psychiatry : the journal of the Association of European Psychiatrists · 2023Review
- A generalizable connectome-based marker of in-scan sustained attention in neurodiverse youth.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- New and emerging approaches to treat psychiatric disorders.Nature medicine · 2023Review
- Exploring the latent structure of behavior using the Human Connectome Project's data.Scientific reports · 2023Article
- Experimental Medicine Approaches in Early-Phase CNS Drug Development.Advances in neurobiology · 2023Article
- Clinical Utility of Fluid Biomarker in Depressive Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2022Review
- Functional Connectome-Based Predictive Modeling in Autism.Biological psychiatry · 2022Review
- Another failure of the latent disease model? The case of compulsive sexual behavior disorder •.Journal of behavioral addictions · 2022Article
- Schizophrenia: A Narrative Review of Etiopathogenetic, Diagnostic and Treatment Aspects.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Research Domain Criteria (RDoC) paradigm was launched 10 years ago as a superior approach for investigation of mental illness. RDoC conceptualizes normal human behavior, emotion, and cognition as dimensional, with mental illnesses as dimensional extremes. We suggest that RDoC may have value for understanding normal human psychology and some conditions plausibly construed as extremes of normal variation. By contrast, for the most serious of mental illnesses, including dementia, autism, schizophrenia, and bipolar disorder, we argue that RDoC is conceptually flawed. RDoC conflates variation along dimensional axes of normal function with quantitative measurements of disease phenotypes and with the occurrence of diseases in overlapping clusters or spectra. This moves away from the disease model of major mental illness. Further, RDoC imposes a top-down approach to research. We argue that progress in major mental illness research will be more rapid with a bottom-up approach, starting with the discovery of etiological factors, proceeding to investigation of pathogenic pathways, including use of cell and animal models, and leading to a refined nosology and novel, targeted treatments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.