Evidence map›Paper›PMID 31768361›Full record

ReviewOcular oncology and pathology2019

Conjunctival Melanoma in Childhood and Adolescence: A Systematic Review.

Ben W R Balzer, Svetlana Cherepanoff, Anthony M Joshua, Michael Giblin, Robert Max Conway, Antoinette C Anazodo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Ocular oncology and pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Epidemiological and histopathological aspects of ocular melanomas in Northeastern Romania.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Article
  6. Clinical and immunohistopathological study of conjunctival melanocytic lesions in pediatric and adolescent patients. A case series.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Ben W R BalzerSydney Children's Hospital, Randwick, New South Wales, Australia.
Svetlana CherepanoffSt. Vincent's Hospital, Darlinghurst, New South Wales, Australia.
Anthony M JoshuaSt. Vincent's Hospital, Darlinghurst, New South Wales, Australia.
Michael GiblinSydney Eye Hospital, Sydney, New South Wales, Australia.
Robert Max ConwaySave Sight Institute, University of Sydney, Sydney, New South Wales, Australia.
Antoinette C AnazodoSydney Children's Hospital, Randwick, New South Wales, Australia.
The University of Sydney · AUUNSW Sydney · AUSt Vincent's Hospital Sydney · AUSydney Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundConjunctival melanoma is rare in adults and rarer in children. We systematically reviewed the presentation, diagnostic and management strategies as well as outcomes for conjunctival melanoma in children and adolescents.

methodsThe following databases were searched: Medline, Embase, Web of Science and Scopus for cases of conjunctival melanoma occurring in children and adolescents < 18 years of age.

resultsSeventeen studies with 32 patients (18 males) were identified. The median age at presentation was 11 years (range 4-18 years). Most patients were white. Most patients presented with a conjunctival mass or naevus with a recent history of growth or change. Excision biopsy provided diagnosis and management for all cases. Adjuvant chemotherapy and radiotherapy were also used. One patient had metastatic disease at diagnosis and 3 developed metastatic disease (range 1-10 months). Two patients died from disease and one was alive with metastatic disease. Two patients had disease recurrence. Outcomes were observed to be better where diagnosis was made earlier and "no-touch" excision biopsy was performed in an appropriate specialist setting.

conclusionsConjunctival melanoma occurs rarely in children and adolescents. Surgery is the mainstay of management. The prognosis is guarded in metastatic disease due to the small sample size and limited follow-up.

Indexed as

Conjunctival melanomaPaediatric oncologyPaediatric ophthalmology

Identifiers

PMID31768361
PMCPMC6873081
OpenAlexW2936332834

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.