ArticleGastrointestinal tumors2019
Proinsulin-Secreting Neuroendocrine Tumors of the Pancreas: A Single-Centre Experience.
Article in Gastrointestinal tumors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 3 citations in OpenAlex.
- Metastatic proinsulin-secreting tumor: a rare cause of persistent hypoglycemia.JCEM case reports · 2026Article
- Proinsulinoma Unmasked by Intermittent Fasting: A Case of Endogenous Proinsulinaemic Hypoglycaemia.Case reports in endocrinology · 2026Article
- A Novel Somatic Mutation Implicates ATP6V0D1 in Proinsulin Processing.Journal of the Endocrine Society · 2023Article
- Intraoperative selective arterial calcium injection test to confirm complete resection of a proinsulinoma.Journal of surgical case reports · 2022Article
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Authors and funding
7 authors.
Funding
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Abstract
backgroundProinsulinoma is a neuroendocrine tumor (NET) of the pancreas that produces prohormone proinsulin. These tumors are very rare. In the literature, they are most often presented in the form of case reports. MATERIALS AND
methodsWe studied 177 patients with NET of the pancreas who underwent surgical treatment in the A.V. Vishnevsky National Medical Research Centre of Surgery from January 2007 to December 2018.
resultsOf 81 patients with organic hyperinsulinism caused by functioning NETs of the pancreas during the study period, 3 (3.7%) had a proinsulinoma; 2 were female; and 1 was male. None of them admitted to weight gain during this period, and their BMI was normal. All patients presented with Whipple's triad during the 72-h fast. Tumor-enucleating surgery was performed: one robot assisted, two laparotomies. A normal glucose level after treatment was achieved in all cases.
conclusionIn cases where clinical hypoglycemia is present, but the serum insulin level is within the normal range or even decreased, proinsulinoma should be suspected. For now, surgical resection remains the only effective method of treatment. Further investigation of pro-insulinomas is needed.
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