ArticleBiomaterials research2019
Effect of photoinitiator on chain degradation of hyaluronic acid.
Article in Biomaterials research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 53 citations in OpenAlex.
- Spatiotemporally programmed tissue regeneration via visible-light-responsive hydrogels: Biosafety-oriented design and applications.Materials today. Bio · 2026Review
- Rational structural design for the dual enhancement of catalytic activity and thermal stability of hyaluronidase from Citrobacter portucalensis.Biotechnology for biofuels and bioproducts · 2026Article
- Protective Functions of β-Alanyl-L-Histidine and Glycyl-L-Histidyl-L-Lysine Glycoconjugates and Copper in Concert.Antioxidants (Basel, Switzerland) · 2025Review
- Spectroscopic and Rheological Characterization of Polyvinyl Alcohol/Hyaluronic Acid-Based Systems: Effect of Polymer Ratio and Riboflavin on Hydrogel Properties.Gels (Basel, Switzerland) · 2025Article
- Bioprinting Vascularized Constructs for Clinical Relevance: Engineering Hydrogel Systems for Biological Maturity.Gels (Basel, Switzerland) · 2025Review
- Hyaluronic acid as a versatile building block for the development of biofunctional hydrogels: In vitro models and preclinical innovations.Materials today. Bio · 2025Article
- A New Light-Sensor System Affecting Cancer Cell Fate.Biomaterials research · 2025Article
- 3D Bioprintable Self-Healing Hyaluronic Acid Hydrogel with Cysteamine Grafting for Tissue Engineering.Gels (Basel, Switzerland) · 2024Article
- Injectable Microparticle-containing hydrogel with controlled release of bioactive molecules for facial rejuvenation.Materials today. Bio · 2024Article
- Green Chemistry for Crosslinking Biopolymers: Recent Advances in Riboflavin-Mediated Photochemistry.Materials (Basel, Switzerland) · 2023Review
- Enzyme-Mediated Alleviation of Peroxide Toxicity in Self-Oxygenating Biomaterials.Advanced healthcare materials · 2022Article
- 3D bioprinting and photocrosslinking: emerging strategies & future perspectives.Biomaterials advances · 2022Review
- Prospective bacterial and fungal sources of hyaluronic acid: A review.Computational and structural biotechnology journal · 2022Review
- Phenol-Hyaluronic Acid Conjugates: Correlation of Oxidative Crosslinking Pathway and Adhesiveness.Polymers · 2021Article
- The effects of the molecular weights of hyaluronic acid on the immune responses.Biomaterials research · 2021Article
- Light-cured hyaluronic acid composite hydrogels using riboflavin as a photoinitiator for bone regeneration applications.Journal of Taibah University Medical Sciences · 2021Article
- Visible Light-Curable Chitosan Ink for Extrusion-Based and Vat Polymerization-Based 3D Bioprintings.Polymers · 2021Article
- Green photosensitisers for the degradation of selected pesticides of high risk in most susceptible food: A safer approach.PloS one · 2021Article
- Stimuli-Responsive Rifampicin-Based Macromolecules.Materials (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPhotocrosslinking systems of polymers have been widely studied using UV or visible light irradiation. However, the photodegradation behavior derived from light irradiation was rarely reported, comparing with the photocrosslinking. In this study, the tyramine-modified hyaluronic acid (HA/Tyr) hydrogel was prepared using riboflavin (RF) as a photoinitiator, and the degradation behavior of HA by the reactive oxygen species (ROS) generated in photochemical process was investigated. MATERIALS AND
methodsThe HA/Tyr conjugate was synthesized by EDC/NHS chemistry to introduce phenol group. Degree of substitution (DS, %) of phenol group to HA molecule was about 25%. The structural change of HA/Tyr was measured by proton nuclear magnetic resonance (
resultsThe HA/Tyr solution with 25% substitution formed a stable hydrogel via visible light irradiation in the presence of RF photoinitiator. Rheological data of HA/Tyr solution showed that the storage modulus (G') was increased with increasing HA concentration. Additionally, it was found that RF initiated by visible light irradiation induced the degradation of HA molecular chain, and consequently reduced the viscosity of HA/Tyr solutions.
conclusionThe results indicate that RF-based photoinitiator system caused the degradation of HA molecule by ROS generated in photochemical process as well as the crosslinking of HA/Tyr.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.