Evidence map›Paper›PMID 31768252›Full record

Observational studyAntimicrobial resistance and infection control2019

Pattern of inappropriate antibiotic use among hospitalized patients in Pakistan: a longitudinal surveillance and implications.

Zikria Saleem, Hamid Saeed, Mohamed Azmi Hassali, Brian Godman, Usama Asif, Mahrukh Yousaf, Zakiuddin Ahmed, Humayun Riaz, Syed Atif Raza

Abstract readObservational Study
In one paragraph

Observational study in Antimicrobial resistance and infection control, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Article
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  5. Analysis of Antibiotic Resistance Patterns and Distribution ofThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zikria Saleem1School of Pharmaceutical Sciences, Universiti Sains Malaysia, Gelugor, Malaysia.ORCID 0000-0003-3202-6347
Hamid Saeed3University College of Pharmacy, University of the Punjab, Lahore, Pakistan.
Mohamed Azmi Hassali1School of Pharmaceutical Sciences, Universiti Sains Malaysia, Gelugor, Malaysia.
Brian Godman1School of Pharmaceutical Sciences, Universiti Sains Malaysia, Gelugor, Malaysia.
Usama AsifMedical Centre, Agha Khan University Hospital, Karachi, Pakistan.
Mahrukh YousafMedical Centre, Agha Khan University Hospital, Karachi, Pakistan.
Zakiuddin AhmedRipha Institute of Healthcare Improvement & Safety, Ripha University, Islamabad, Pakistan.
Humayun RiazRashid Latif College of Pharmacy, Lahore, Pakistan.
Syed Atif Raza3University College of Pharmacy, University of the Punjab, Lahore, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The inappropriate use of antibiotics in hospitals increases resistance, morbidity, and mortality. Little is currently known about appropriate antibiotic use among hospitals in Lahore, the capital city of Pakistan. Methods: Longitudinal surveillance was conducted over a period of 2 months among hospitals in Lahore, Pakistan. Antibiotic treatment was considered inappropriate on the basis of a wrong dosage regimen, wrong indication, or both based on the British National Formulary. Results: A total of 2022 antibiotics were given to 1185 patients. Out of the total prescribed, approximately two-thirds of the study population (70.3%) had at least one inappropriate antimicrobial. Overall, 27.2% of patients had respiratory tract infections, and out of these, 62.8% were considered as having inappropriate therapy. Cephalosporins were extensively prescribed among patients, and in many cases, this was inappropriate (67.2%). Penicillins were given to 283 patients, out of which 201 (71.0%) were prescribed for either the wrong indication or dosage or both. Significant variations were also observed regarding inappropriate prescribing for several antimicrobials including the carbapenems (70.9%), aminoglycosides (35.8%), fluoroquinolones (64.2%), macrolides (74.6%) and other antibacterials (73.1%). Conclusion: Educational interventions, institutional guidelines, and antimicrobial stewardship programs need to be developed to enhance future appropriate antimicrobial use in hospitals in Pakistan. Policies by healthcare and Government officials are also needed to minimize inappropriate antibiotic use.

Indexed as

HospitalizationAnti-Bacterial AgentsAntimicrobial StewardshipDrug PrescriptionsFemaleHospitalsHumansInappropriate PrescribingLongitudinal StudiesMalePakistanPractice Patterns, Physicians'Public Health SurveillanceAnti-Bacterial AgentsAntibiotics, hospitalsAppropriatenessPakistanPrescribing

Identifiers

PMID31768252
PMCPMC6873729

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.