Evidence map›Paper›PMID 31768059›Full record

ArticleNature methods2020

A CMOS NMR needle for probing brain physiology with high spatial and temporal resolution.

Jonas Handwerker, Marlon Pérez-Rodas, Michael Beyerlein, Franck Vincent, Armin Beck, Nicolas Freytag, Xin Yu, Rolf Pohmann, Jens Anders, Klaus Scheffler

Abstract read
PubMed Publisher
In one paragraph

Article in Nature methods, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 55 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Jonas HandwerkerInstitute of Smart Sensors, University of Stuttgart, Stuttgart, Germany. jonas.handwerker@iis.uni-stuttgart.de.ORCID http://orcid.org/0000-0002-6098-051X
Marlon Pérez-RodasDepartment for High-field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.
Michael BeyerleinDepartment for Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.
Franck VincentBruker BioSpin AG, Fällanden, Switzerland.
Armin BeckBruker BioSpin AG, Fällanden, Switzerland.
Nicolas FreytagBruker BioSpin AG, Fällanden, Switzerland.
Xin YuDepartment for High-field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.ORCID http://orcid.org/0000-0001-9890-5489
Rolf PohmannDepartment for High-field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.ORCID http://orcid.org/0000-0002-6137-9590
Jens Anders *Institute of Smart Sensors, University of Stuttgart, Stuttgart, Germany. jens.anders@iis.uni-stuttgart.de.ORCID http://orcid.org/0000-0002-2498-0352
Klaus Scheffler *Department for High-field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany. klaus.scheffler@tuebingen.mpg.de.ORCID http://orcid.org/0000-0001-6316-8773
Max Planck Institute for Biological Cybernetics · DEBruker (Switzerland) · CHUniversity of Stuttgart · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnetic resonance imaging and spectroscopy are versatile methods for probing brain physiology, but their intrinsically low sensitivity limits the achievable spatial and temporal resolution. Here, we introduce a monolithically integrated NMR-on-a-chip needle that combines an ultra-sensitive 300 µm NMR coil with a complete NMR transceiver, enabling in vivo measurements of blood oxygenation and flow in nanoliter volumes at a sampling rate of 200 Hz.

Indexed as

AnimalsBlood Flow VelocityBrainImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleOxygenRatsRats, Sprague-DawleyOxygen

Identifiers

PMID31768059
OpenAlexW2989677634

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.