ArticleScientific reports2019
Evaluation of longitudinal time-lapsed in vivo micro-CT for monitoring fracture healing in mouse femur defect models.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Dynamic Assessment of Cortical Porosity in Preclinical Models: Time-lapse Imaging of Cortical Remodeling.Current osteoporosis reports · 2026Review
- Advances in Spatial Transcriptomics in Bone.Current osteoporosis reports · 2026Review
- Specimen preparation for X-ray micro-computed tomography of forest pests.Applied microscopy · 2025Review
- Culture system for longitudinal monitoring of bone dynamics ex vivo.Biotechnology and bioengineering · 2025Article
- A study on early diagnosis for fracture non-union prediction using deep learning and bone morphometric parameters.Frontiers in medicine · 2025Article
- The effect of favipiravir on fracture healing.Acta orthopaedica et traumatologica turcica · 2024Article
- Image Registration in Longitudinal Bone Assessment Using Computed Tomography.Current osteoporosis reports · 2023Review
- Temporal Pattern of micro-CT Angiography Vascular Parameters and VEGF mRNA Expression in Fracture Healing: a Radiograph and Molecular Comparison.European journal of dentistry · 2023Article
- The effects of cephalexin on fracture healing in a rat femur fracture model.Joint diseases and related surgery · 2023Article
- Clinical Assessments of Fracture Healing and Basic Science Correlates: Is There Room for Convergence?Current osteoporosis reports · 2023Review
- AnFrontiers in bioengineering and biotechnology · 2023Article
- X-ray computed microtomography datasets for osteogenic nanofibrous coated titanium implants.Scientific data · 2022Article
- Epimorphic regeneration of the mouse digit tip is finite.Stem cell research & therapy · 2022Article
- Validation of the modified radiographic union score for tibia fractures (mRUST) in murine femoral fractures.Frontiers in endocrinology · 2022Article
- Tissue-Level Regeneration and Remodeling Dynamics are Driven by Mechanical Stimuli in the Microenvironment in a Post-Bridging Loaded Femur Defect Healing Model in Mice.Frontiers in cell and developmental biology · 2022Article
- Individualized cyclic mechanical loading improves callus properties during the remodelling phase of fracture healing in mice as assessed from time-lapsed in vivo imaging.Scientific reports · 2021Article
- Article
- Characterization of the Developing Lacunocanalicular Network During Fracture Repair.JBMR plus · 2021Article
- Real-time finite element analysis allows homogenization of tissue scale strains and reduces variance in a mouse defect healing model.Scientific reports · 2021Article
- Micro-CT data of early physiological cancellous bone formation in the lumbar spine of female C57BL/6 mice.Scientific data · 2021Article
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6 authors.
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Abstract
Longitudinal in vivo micro-computed tomography (micro-CT) is of interest to non-invasively capture the healing process of individual animals in preclinical fracture healing studies. However, it is not known whether longitudinal imaging itself has an impact on callus formation and remodeling. In this study, a scan group received weekly micro-CT measurements (week 0-6), whereas controls were only scanned post-operatively and at week 5 and 6. Registration of consecutive scans using a branching scheme (bridged vs. unbridged defect) combined with a two-threshold approach enabled assessment of localized bone turnover and mineralization kinetics relevant for monitoring callus remodeling. Weekly micro-CT application did not significantly change any of the assessed callus parameters in the defect and periosteal volumes. This was supported by histomorphometry showing only small amounts of cartilage residuals in both groups, indicating progression towards the end of the healing period. Also, immunohistochemical staining of Sclerostin, previously associated with mediating adverse radiation effects on bone, did not reveal differences between groups. The established longitudinal in vivo micro-CT-based approach allows monitoring of healing phases in mouse femur defect models without significant effects of anesthesia, handling and radiation on callus properties. Therefore, this study supports application of longitudinal in vivo micro-CT for healing-phase-specific monitoring of fracture repair in mice.
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