Evidence map›Paper›PMID 31767928›Full record

ArticleScientific reports2019

Altered processing enhances the efficacy of small-diameter silk fibroin vascular grafts.

Alex H P Chan, Elysse C Filipe, Richard P Tan, Miguel Santos, Nianji Yang, Juichien Hung, Jieyao Feng, Sidra Nazir, Alexander J Benn, Martin K C Ng and 2 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Recent Advances in Silk Fibroin Derived fromJournal of functional biomaterials · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. The Application of Porous Scaffolds for Cardiovascular Tissues.Bioengineering (Basel, Switzerland) · 2023
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Alex H P ChanThe Heart Research Institute, 7 Eliza Street, Newtown, Sydney, NSW, 2042, Australia.ORCID http://orcid.org/0000-0002-1244-7673
Elysse C FilipeGarvan Institute of Medical Research & The Kinghorn Cancer Center, Sydney, NSW, 2010, Australia.
Richard P TanThe Heart Research Institute, 7 Eliza Street, Newtown, Sydney, NSW, 2042, Australia.
Miguel SantosThe Heart Research Institute, 7 Eliza Street, Newtown, Sydney, NSW, 2042, Australia.
Nianji YangThe Heart Research Institute, 7 Eliza Street, Newtown, Sydney, NSW, 2042, Australia.
Juichien HungThe Heart Research Institute, 7 Eliza Street, Newtown, Sydney, NSW, 2042, Australia.
Jieyao FengThe Heart Research Institute, 7 Eliza Street, Newtown, Sydney, NSW, 2042, Australia.
Sidra NazirThe Heart Research Institute, 7 Eliza Street, Newtown, Sydney, NSW, 2042, Australia.
Alexander J BennThe Heart Research Institute, 7 Eliza Street, Newtown, Sydney, NSW, 2042, Australia.
Martin K C NgSydney Medical School, University of Sydney, Sydney, NSW, 2006, Australia.
Jelena Rnjak-KovacinaGraduate School of Biomedical Engineering, UNSW Sydney, Sydney, NSW, 2052, Australia. j.rnjak-kovacina@unsw.edu.au.
Steven G WiseThe Heart Research Institute, 7 Eliza Street, Newtown, Sydney, NSW, 2042, Australia. steven.wise@sydney.edu.au.
The Heart Research Institute · AUThe University of Sydney · AUGarvan Institute of Medical Research · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current synthetic vascular grafts are not suitable for use in low-diameter applications. Silk fibroin is a promising natural graft material which may be an effective alternative. In this study, we compared two electrospun silk grafts with different manufacturing processes, using either water or hexafluoroisopropanol (HFIP) as solvent. This resulted in markedly different Young's modulus, ultimate tensile strength and burst pressure, with HFIP spun grafts observed to have thicker fibres, and greater stiffness and strength relative to water spun. Assessment in a rat abdominal aorta grafting model showed significantly faster endothelialisation of the HFIP spun graft relative to water spun. Neointimal hyperplasia in the HFIP graft also stabilised significantly earlier, correlated with an earlier SMC phenotype switch from synthetic to contractile, increasing extracellular matrix protein density. An initial examination of the macrophage response showed that HFIP spun conduits promoted an anti-inflammatory M2 phenotype at early timepoints while reducing the pro-inflammatory M1 phenotype relative to water spun grafts. These observations demonstrate the important role of the manufacturing process and physical graft properties in determining the physiological response. Our study is the first to comprehensively study these differences for silk in a long-term rodent model.

Indexed as

Blood Vessel ProsthesisFibroinsAnimalsAorta, AbdominalBombyxElastic ModulusElastinHydrocarbons, FluorinatedHyperplasiaMaleMaterials TestingMicroscopy, Electron, ScanningNeointimaPorosityPropanolsProsthesis DesignElastinFibroinshexafluoroisopropanolHydrocarbons, FluorinatedPropanolsSolventsWater

Identifiers

PMID31767928
PMCPMC6877724
OpenAlexW2991183995

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.