Evidence map›Paper›PMID 31767892›Full record

ArticleScientific reports2019

Immunophenotypes associated with bipolar disorder and lithium treatment.

Tai-Na Wu, Chau-Shoun Lee, Bo-Jian Wu, Hsiao-Ju Sun, Chieh-Hsing Chang, Chun-Ying Chen, Chih-Ken Chen, Lawrence Shih-Hsin Wu, Andrew Tai-Ann Cheng

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
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  4. The Mechanisms of Lithium Action: The Old and New Findings.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
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  9. Review
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  11. Review
  12. New Paradigms of Old Psychedelics in Schizophrenia.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  13. Review
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Tai-Na WuInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Chau-Shoun LeeDepartment of Medicine, MacKay Medical College; Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan.
Bo-Jian WuYuli hospital, Ministry of Health and Welfare, Hualien, Taiwan.
Hsiao-Ju SunYuli hospital, Ministry of Health and Welfare, Hualien, Taiwan.
Chieh-Hsing ChangTsao-Tun Psychiatric Center, Ministry of Health and Welfare, Nantou, Taiwan.
Chun-Ying ChenTsao-Tun Psychiatric Center, Ministry of Health and Welfare, Nantou, Taiwan.
Chih-Ken ChenSchool of Medicine, Chang Gung University; Community Medicine Research Center & Department of Psychiatry, Chang Gung Memorial Hospital, Keelung, Taiwan. kenchen@cgmh.org.tw.
Lawrence Shih-Hsin WuGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan. lshwu@hotmail.com.
Andrew Tai-Ann ChengInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. bmandrew@gate.sinica.edu.tw.
Ministry of Health and Welfare · TWChina Medical University · TWBali Psychiatric Center · TWChang Gung Memorial Hospital · TWInstitute of Biomedical Sciences, Academia Sinica · TWMackay Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune dysfunction is implicated in the etiology of bipolar disorder. The single-nucleotide polymorphism rs17026688 in the gene encoding glutamate decarboxylase-like protein 1 (GADL1) has been found to be associated with lithium response in Han Chinese patients with bipolar I disorder (BDI). However, whether patients with GADL1 polymorphisms have different immunophenotypes is unknown. To address this issue, differences in the immune profiles based on analysis of peripheral blood mononuclear cells (PBMCs) were compared among BDI patients and healthy controls who lack or carry the T allele of rs17026688. BDI patients had significantly higher percentages of total T cells, CD4

Indexed as

Polymorphism, Single NucleotideAdultAntigens, CDAsian PeopleBipolar DisorderCarboxy-LyasesEthnicityFemaleHumansImmunophenotypingLithium CarbonateLymphocyte SubsetsMaleMiddle AgedMyeloid-Derived Suppressor CellsPsychotropic DrugsAntigens, CDCarboxy-LyasesGADL1 protein, humanLithium CarbonatePsychotropic Drugs

Identifiers

PMID31767892
PMCPMC6877517
OpenAlexW2989615262

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.