ArticleNature communications2019
Global chromatin conformation differences in the Drosophila dosage compensated chromosome X.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- CRM-TI: an enhanced pipeline for computationally assigning the target genes of cis-regulatory modules by considering comprehensive long-range regulation mechanisms.BioData mining · 2026Article
- Trait-specific chromatin architectures channel pleiotropic genes toward sexually dimorphic development in horned beetles.bioRxiv : the preprint server for biology · 2026Article
- Evolution and regulation of animal sex chromosomes.Nature reviews. Genetics · 2025Review
- Development and evolution of Drosophila chromatin landscape in a 3D genome context.Nature communications · 2024Article
- Set2 and H3K36 regulate the Drosophila male X chromosome in a context-specific manner, independent from MSL complex spreading.Genetics · 2024Article
- siRNA that participates in Drosophila dosage compensation is produced by many 1.688X and 359 bp repeats.Genetics · 2024Article
- Set2 and H3K36 regulate thebioRxiv : the preprint server for biology · 2024Article
- The N-Terminal Part ofInternational journal of molecular sciences · 2023Article
- Mechanisms of Interaction between Enhancers and Promoters in ThreeInternational journal of molecular sciences · 2023Review
- Dosage Compensation inInternational journal of molecular sciences · 2022Review
- Polycomb-mediated genome architecture enables long-range spreading of H3K27 methylation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Comparison of genome architecture at two stages of male germline cell differentiation in Drosophila.Nucleic acids research · 2022Article
- Polymer Modeling of 3D Epigenome Folding: Application to Drosophila.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Mechanisms of enhancer-promoter communication and chromosomal architecture in mammals andFrontiers in genetics · 2022Review
- Visualizing and Annotating Hi-C Data.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Mechanisms of CP190 Interaction with Architectural Proteins in Drosophila Melanogaster.International journal of molecular sciences · 2021Article
- Leveraging three-dimensional chromatin architecture for effective reconstruction of enhancer-target gene regulatory interactions.Nucleic acids research · 2021Article
- Live imaging and biophysical modeling support a button-based mechanism of somatic homolog pairing ineLife · 2021Article
- Analysis of cell-type-specific chromatin modifications and gene expression in Drosophila neurons that direct reproductive behavior.PLoS genetics · 2021Article
- A Hypothesis: Linking Phase Separation to Meiotic Sex Chromosome Inactivation and Sex-Body Formation.Frontiers in cell and developmental biology · 2021Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Drosophila melanogaster the single male chromosome X undergoes an average twofold transcriptional upregulation for balancing the transcriptional output between sexes. Previous literature hypothesised that a global change in chromosome structure may accompany this process. However, recent studies based on Hi-C failed to detect these differences. Here we show that global conformational differences are specifically present in the male chromosome X and detectable using Hi-C data on sex-sorted embryos, as well as male and female cell lines, by leveraging custom data analysis solutions. We find the male chromosome X has more mid-/long-range interactions. We also identify differences at structural domain boundaries containing BEAF-32 in conjunction with CP190 or Chromator. Weakening of these domain boundaries in male chromosome X co-localizes with the binding of the dosage compensation complex and its co-factor CLAMP, reported to enhance chromatin accessibility. Together, our data strongly indicate that chromosome X dosage compensation affects global chromosome structure.
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