ArticleCell death & disease2019
Loss of ubiquitin-conjugating enzyme E2 (Ubc9) in macrophages exacerbates multiple low-dose streptozotocin-induced diabetes by attenuating M2 macrophage polarization.
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Article in Cell death & disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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41citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
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41 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Differentiation state affects PD-L1 expression in cutaneous melanoma: a systematic review.Cellular & molecular biology letters · 2026Pooled it
- Interferon regulatory factors orchestrate CD8International journal of molecular medicine · 2026Review
- SUMO2-mediated SP1 SUMOylation promotes M2 macrophage polarization to facilitate diabetic foot ulcer healing.Molecular and cellular biochemistry · 2026Article
- Fludarabine disrupts the STAT1/AhR interaction to attenuate type 1 diabetes by inducing tolerogenic dendritic cells along with targeting effector T cells.Molecular medicine (Cambridge, Mass.) · 2026Article
- Unveiling the Hub Genes Associated with the Enhanced Effects of Selenium on Pancreas Function in Diabetic Mice.Molecular biotechnology · 2026Article
- Ubc9-Mediated SUMOylation of RPL3, an Unappreciated Mechanism against Hepatocyte Senescence by Repressing the DHX9-p16 Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- [Human umbilical cord mesenchymal stem cell grafting alleviates inflammatory response in type 1 diabetic mice by suppressing M1 macrophage polarization through Chi3l1].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- LAMP5 modulates IRF4 stability and nuclear transport: a critical mechanism in myeloma progression and therapy.Oncogene · 2025Article
- Pancreatic β-cell FFA2 deficiency suppresses multiple low dose streptozotocin induced diabetes in male mice.Communications biology · 2025Article
- SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Genetic Ablation of the Conidiogenesis Regulator Enhances Mycoprotein Production.Journal of agricultural and food chemistry · 2025Article
- Immunoregulatory iPSC-derived non-lymphoid progeny in autoimmunity and GVHD alloimmunity.Stem cells (Dayton, Ohio) · 2025Review
- The multiple roles of interferon regulatory factor family in health and disease.Signal transduction and targeted therapy · 2024Review
- Suppression of SENP3 enhances macrophage alternative activation by mediating IRF4 de-SUMOylation in ESCC progression.Cell communication and signaling : CCS · 2024Article
- PDIA3 orchestrates effector T cell program by serving as a chaperone to facilitate the non-canonical nuclear import of STAT1 and PKM2.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Post-Translational Modifications and Diabetes.Biomolecules · 2024Review
- Ubiquitin-conjugating enzyme E2 for regulating autophagy in diabetic cardiomyopathy: A mini-review.Journal of diabetes · 2024Review
- Tissue adaptation to metabolic stress: insights from SUMOylation.Frontiers in endocrinology · 2024Review
- Ubc9 regulates the expression of MHC II in dendritic cells to enhance DSS-induced colitis by mediating RBPJ SUMOylation.Cell death & disease · 2023Article
- FSTL1 Suppresses Triple-Negative Breast Cancer Lung Metastasis by Inhibiting M2-like Tumor-Associated Macrophage Recruitment toward the Lungs.Diagnostics (Basel, Switzerland) · 2023Article
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Authors and funding
23 authors at 6 institutions in 3 countries.
Faxi WangThe Center for Biomedical Research, Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences,Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Fei SunThe Center for Biomedical Research, Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences,Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Jiahui LuoThe Center for Biomedical Research, Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences,Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Tiantian YueThe Center for Biomedical Research, Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences,Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Longmin ChenThe Center for Biomedical Research, Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences,Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Haifeng ZhouThe Center for Biomedical Research, Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences,Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Jing ZhangThe Center for Biomedical Research, Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences,Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Chunliang YangThe Center for Biomedical Research, Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences,Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Xi LuoThe Center for Biomedical Research, Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences,Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Qing ZhouThe Center for Biomedical Research, Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences,Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
He ZhuThe Center for Biomedical Research, Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences,Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Jinxiu LiShenzhen Third People's Hospital, 29 Bujibulan Road, Longgang District, 518000, Shenzhen, Guangdong, China.
Ping YangThe Center for Biomedical Research, Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences,Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Fei XiongThe Center for Biomedical Research, Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences,Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Qilin YuThe Center for Biomedical Research, Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences,Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Huilan ZhangDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Wanguang ZhangDepartment of Abdominal Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Aimin XuThe State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, 21 Sassoon Road, Laboratory Block, Pokfulam, Hong Kong, China.ORCID http://orcid.org/0000-0002-0668-033X
Zhiguang ZhouDiabetes Center, The Second Xiangya Hospital, Institute of Metabolism and Endocrinology, Central South University, Changsha, China.
Qianjin LuDepartment of Dermatology, Hunan Key Laboratory of Medical Epigenomics, Second Xiangya Hospital of Central South University, Changsha, China.
Decio L EizirikULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.
Shu ZhangThe Center for Biomedical Research, Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences,Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China. szhang@tjh.tjmu.edu.cn.
Cong-Yi WangThe Center for Biomedical Research, Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences,Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China. wangcy@tjh.tjmu.edu.cn.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNCentral South University · CNTongji Hospital · CNShenzhen Third People’s Hospital · CNState Key Laboratory of Synthetic Chemistry · CNUniversité Libre de Bruxelles · BE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 1 diabetes (T1D) is characterized by the selective autoimmune destruction of the islet β cells, and macrophages play a significant role in this process. Small ubiquitin-like modification (SUMOylation) is an important posttranslational modification involved in T1D pathogenesis, but its function in macrophages remains unexplored. We presently developed and used macrophage-specific ubiquitin-conjugating enzyme E2 (Ubc9) knockout (LyzM-Cre-Ubc9
Indexed as
Cell PolarityDisease ProgressionAnimalsAntigensArginaseBone Marrow CellsCell MovementCell NucleusCell RespirationCytokinesDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1GlycolysisInflammationInterferon Regulatory Factor-4Interferon Regulatory FactorsAntigensArginaseCytokinesInterferon Regulatory Factor-4Interferon Regulatory FactorsStreptozocinUbiquitin-Conjugating EnzymesUbiquitin-Conjugating Enzyme UBC9
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