ArticleProceedings of the National Academy of Sciences of the United States of America2019
Photoperiodic and clock regulation of the vitamin A pathway in the brain mediates seasonal responsiveness in the monarch butterfly.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 78 citations in OpenAlex.
- Environmental and Genetic Conditions Shaping Monarch Butterfly Migration Biology.Animal behaviour · 2026Article
- Early photoperiodic cues modulate capacity for adult cold tolerance in the yellow fever mosquito Aedes aegypti.The Journal of experimental biology · 2026Article
- Emerging tools to advance neuroethology in butterflies and moths.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- Cryptochrome-mediated integration of circadian rhythms into seasonal cycles in the silkwormFrontiers in physiology · 2026Review
- A Peptidergic Neural System Connects the Circadian Clock to the Photoperiodic Control of Reproductive Diapause in the BugThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The cycle gene is essential for both daily responses and seasonal reproduction in the Northern house mosquito, Culex pipiens.Scientific reports · 2025Article
- Noncanonical action of circadian clock genes controls winter diapause entry via the NuA4/TIP60 complex inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Comparative Analysis of Diel and Circadian Eclosion Rhythms and Clock Gene Expression Between Sexes in the Migratory MothInsects · 2025Article
- Molecular basis governing diapause and pigmentation in the hawthorn spider mite, Amphitetranychus viennensis.BMC biology · 2025Article
- Novel genetic association with migratory diapause in Australian monarch butterflies.BMC ecology and evolution · 2025Article
- Molecular basis of circadian rhythm divergence between diurnal and nocturnal lepidoperans.iScience · 2025Article
- The PBAP chromatin remodeling complex mediates summer diapause via H3K4me3-driven juvenile hormone regulation inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Increased Evolutionary Rate in the Z chromosome of Sympatric and Allopatric Species of Morpho Butterflies.Genome biology and evolution · 2024Article
- CRY1 is involved in the take-off behaviour of migratory Cnaphalocrocis medinalis individuals.BMC biology · 2024Article
- Testing for variation in photoperiodic plasticity in a butterfly: Inconsistent effects of circadian genes between geographic scales.Ecology and evolution · 2024Article
- Loss of functionaliScience · 2024Article
- Novel Insights into the Circadian Rhythms Based on Long Noncoding and Circular RNA Profiling.International journal of molecular sciences · 2024Article
- Editorial: Rising stars in chronobiology 2022.Frontiers in physiology · 2024Article
- Article
- Migration genetics take flight: genetic and genomic insights into monarch butterfly migration.Current opinion in insect science · 2023Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Seasonal adaptation to changes in light:dark regimes (i.e., photoperiod) allows organisms living at temperate latitudes to anticipate environmental changes. In nearly all animals studied so far, the circadian system has been implicated in measurement and response to the photoperiod. In insects, genetic evidence further supports the involvement of several clock genes in photoperiodic responses. Yet, the key molecular pathways linking clock genes or the circadian clock to insect photoperiodic responses remain largely unknown. Here, we show that inactivating the clock in the North American monarch butterfly using loss-of-function mutants for the circadian activators CLOCK and BMAL1 and the circadian repressor CRYPTOCHROME 2 abolishes photoperiodic responses in reproductive output. Transcriptomic approaches in the brain of monarchs raised in long and short photoperiods, summer monarchs, and fall migrants revealed a molecular signature of seasonal-specific rhythmic gene expression that included several genes belonging to the vitamin A pathway. We found that the rhythmic expression of these genes was abolished in clock-deficient mutants, suggesting that the vitamin A pathway operates downstream of the circadian clock. Importantly, we showed that a CRISPR/Cas9-mediated loss-of-function mutation in the gene encoding the pathway's rate-limiting enzyme,
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.