Evidence map›Paper›PMID 31767725›Full record

ArticleAntimicrobial agents and chemotherapy2020

Population Pharmacokinetics of Intravenous Isavuconazole in Solid-Organ Transplant Recipients.

Xuemei Wu, Raman Venkataramanan, Ryan M Rivosecchi, Chenxiao Tang, Rachel V Marini, Ryan K Shields, Cornelius J Clancy, M Hong Nguyen

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Localized genitourinary tractUrology case reports · 2022
    Article
  10. Article
  11. Article
  12. Isavuconazole Is as Effective as and Better Tolerated Than Voriconazole for Antifungal Prophylaxis in Lung Transplant Recipients.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  13. Article
  14. Review
  15. Article
  16. Reply to Baud and Houzé, "ShouldAntimicrobial agents and chemotherapy · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xuemei WuDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-1640-7385
Raman VenkataramananDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA rv@pitt.edu.
Ryan M RivosecchiDepartment of Pharmacy & Therapeutics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Chenxiao TangDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Rachel V MariniDepartment of Pharmacy & Therapeutics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Ryan K ShieldsDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Cornelius J ClancyDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
M Hong NguyenDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Funding

Caspofungin pharmacokinetics-pharmacodynamics during intra-adbominal candidiasisK08AI114883 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHIELDS, RYAN K · 2015 to 2019
$858k
Characterization and suppression of resistance to new CRE agentsR03AI144636 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHIELDS, RYAN K · 2019 to 2020
$157k
NIAID NIH HHS K08 AI114883NIAID NIH HHS R03 AI144636
6 · The paper itself

Abstract

Isavuconazole (ISA) is a triazole antifungal with activity against yeasts and molds. We established a population pharmacokinetic (pop PK) model of intravenous (i.v.) ISA to identify covariates that affect pharmacokinetics, using plasma samples from solid-organ transplant (SOT) recipients receiving peritransplant prophylaxis. Samples (

Indexed as

Transplant RecipientsAdultAgedAntifungal AgentsArea Under CurveAspergillosisBody Mass IndexCandidiasisFemaleHumansMaleMicrobial Sensitivity TestsMiddle AgedNitrilesNonlinear DynamicsPyridinesAntifungal AgentsisavuconazoleNitrilesPyridinesTriazolesisavuconazolenonlinear mixed-effects modelpopulation pharmacokineticsprobability of PK-PD target attainmentsolid-organ transplantation

Identifiers

PMID31767725
PMCPMC6985716

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.