Evidence map›Paper›PMID 31767724›Full record

ArticleAntimicrobial agents and chemotherapy2020

Linker Editing of Pneumococcal Lysin ClyJ Conveys Improved Bactericidal Activity.

Hang Yang, Dehua Luo, Irina Etobayeva, Xiaohong Li, Yujing Gong, Shujuan Wang, Qiong Li, Poshi Xu, Wen Yin, Jin He and 2 more

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Clinical microbiology reviews · 2025
    Review
  7. Endolysins: targetingFrontiers in microbiology · 2025
    Review
  8. Review
  9. Review
  10. The applications of animal models in phage therapy: An update.Human vaccines & immunotherapeutics · 2023
    Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Phage-Encoded Endolysins.Antibiotics (Basel, Switzerland) · 2021
    Review
  18. Article
  19. Frontiers in cellular and infection microbiology · 2021
    Article
  20. A NovelFrontiers in cellular and infection microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Hang YangCAS Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China yangh@wh.iov.cn nelsond@umd.edu hpwei@wh.iov.cn.
Dehua LuoState Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China.
Irina EtobayevaInstitute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, USA.
Xiaohong LiCAS Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Yujing GongState Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China.
Shujuan WangCAS Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Qiong LiWuhan Polytechnic University, Wuhan, China.
Poshi XuHenan Provincial People's Hospital, Fuwai Central China Cardiovascular Hospital, Zhengzhou, Henan, China.
Wen YinState Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China.
Jin HeState Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China.
Daniel C NelsonInstitute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, USA yangh@wh.iov.cn nelsond@umd.edu hpwei@wh.iov.cn.ORCID 0000-0003-3248-4831
Hongping WeiCAS Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China yangh@wh.iov.cn nelsond@umd.edu hpwei@wh.iov.cn.
Chinese Academy of Sciences · CNHuazhong Agricultural University · CNAdvanced Bioscience Laboratories (United States) · USHenan University · CNWuhan Polytechnic University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntitubercular AgentsBacteremiaCatalytic DomainCell WallCholineFemaleGene EditingMiceMice, Inbred BALB CProtein EngineeringStreptococcus PhagesStreptococcus pneumoniaeStructure-Activity RelationshipAntitubercular AgentsCholineantimicrobial therapybacteriophagebacteriophage lysinchimerachimeric lysinlinker editinglysinStreptococcus pneumoniae

Identifiers

PMID31767724
PMCPMC6985707
OpenAlexW2989750144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.