ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2019
The relative contributions of myocardial perfusion, blood volume and extracellular volume to native T1 and native T2 at rest and during adenosine stress in normal physiology.
Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02723747 (Quantitative Myocardial Perfusion Reserve by Cardiovascular Magnetic Resonance), which is not on this map. Cited by 29 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Quantitative Myocardial Perfusion Reserve by Cardiovascular Magnetic Resonance
Who cites it
29 citing papers in PubMed.
- Stress native mapping does not distinguish patients with previous myocardial infarction with non-obstructive coronary arteries from healthy volunteers.Clinical physiology and functional imaging · 2026Article
- Normal myocardial T1, T2 mapping and extracellular volume at 1.5 T in adult Thai population.Journal of applied clinical medical physics · 2026Article
- Differentiating ischemic from healthy myocardium using cardiovascular magnetic resonance dipyridamole rest and stress T1 mapping.Scientific reports · 2026Article
- Quantitative myocardial mapping using 3.0 T cardiac magnetic resonance imaging in dogs: adenosine stress-rest evaluation.Frontiers in veterinary science · 2026Article
- Myocardial Arterial Spin Labeling with Double Inversion Recovery for reduced physiological noise.Magnetic resonance in medicine · 2025Article
- BMagnetic resonance in medicine · 2025Article
- Long-Term Coronary Microvascular and Cardiac Dysfunction After Severe COVID-19 Hospitalization.JAMA network open · 2025Article
- Stress T1 mapping and quantitative perfusion cardiovascular magnetic resonance in patients with suspected obstructive coronary artery disease.European heart journal. Cardiovascular Imaging · 2025Article
- Biosynthetic gas vesicles as a novel ultrasound contrast agent for diagnosing and treating myocardial infarction.Theranostics · 2025Article
- Quantification of myocardial oxygen extraction fraction on noncontrast MRI enabled by deep learning.Radiology advances · 2024Article
- Improved reproducibility for myocardial ASL: Impact of physiological and acquisition parameters.Magnetic resonance in medicine · 2024Article
- No differences in native T1 of the renal cortex between Fabry disease patients and healthy subjects in cardiac-dedicated native T1 maps.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024Article
- Determining the effect of cardiac blood volume on accuracy of uptake rate constants by simulation.Physics in medicine and biology · 2023Article
- Cardiac Magnetic Resonance Imaging (CMRI) Applications in Patients with Chest Pain in the Emergency Department: A Narrative Review.Diagnostics (Basel, Switzerland) · 2023Review
- Stress native T1 and native T2 mapping compared to myocardial perfusion reserve in long-term follow-up of severe Covid-19.Scientific reports · 2023Article
- Quantification of intramyocardial blood volume usingJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- A 3-slice cardiac quantitative native and post-contrast T1 and T2 MRI protocol requiring only four BHs using a 72-channel receive array coil.Frontiers in cardiovascular medicine · 2023Article
- Acute changes in myocardial tissue characteristics during hospitalization in patients with COVID-19.Frontiers in cardiovascular medicine · 2023Article
- Accelerated cardiac T1 mapping with recurrent networks and cyclic, model-based loss.Medical physics · 2022Article
- Compact MR-compatible ergometer and its application in cardiac MR under exercise stress: A preliminary study.Magnetic resonance in medicine · 2022Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBoth ischemic and non-ischemic heart disease can cause disturbances in the myocardial blood volume (MBV), myocardial perfusion and the myocardial extracellular volume fraction (ECV). Recent studies suggest that native myocardial T1 mapping can detect changes in MBV during adenosine stress without the use of contrast agents. Furthermore, native T2 mapping could also potentially be used to quantify changes in myocardial perfusion and/or MBV. Therefore, the aim of this study was to explore the relative contributions of myocardial perfusion, MBV and ECV to native T1 and native T2 at rest and during adenosine stress in normal physiology.
methodsHealthy subjects (n = 41, 26 ± 5 years, 51% females) underwent 1.5 T cardiovascular magnetic resonance (CMR) scanning. Quantitative myocardial perfusion [ml/min/g] and MBV [%] maps were computed from first pass perfusion imaging at adenosine stress (140 microg/kg/min infusion) and rest following an intravenous contrast bolus (0.05 mmol/kg, gadobutrol). Native T1 and T2 maps were acquired before and during adenosine stress. T1 maps at rest and stress were also acquired following a 0.2 mmol/kg cumulative intravenous contrast dose, rendering rest and stress ECV maps [%]. Myocardial T1, T2, perfusion, MBV and ECV values were measured by delineating a region of interest in the midmural third of the myocardium.
resultsDuring adenosine stress, there was an increase in myocardial native T1, native T2, perfusion, MBV, and ECV (p ≤ 0.001 for all). Myocardial perfusion, MBV and ECV all correlated with both native T1 and native T2, respectively (R
conclusionsMyocardial native T1, native T2, perfusion, MBV, and ECV all increase during adenosine stress. Changes in myocardial native T1 and T2 during adenosine stress in normal physiology can largely be explained by the combined changes in myocardial perfusion and ECV.
trial registrationClinicaltrials.gov identifier NCT02723747. Registered March 16, 2016.
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