Evidence map›Paper›PMID 31766994›Full record

ArticleBMC musculoskeletal disorders2019

Topical cutaneous application of carbon dioxide via a hydrogel for improved fracture repair: results of phase I clinical safety trial.

Takahiro Niikura, Takashi Iwakura, Takashi Omori, Sang Yang Lee, Yoshitada Sakai, Toshihiro Akisue, Keisuke Oe, Tomoaki Fukui, Takehiko Matsushita, Tomoyuki Matsumoto and 1 more

Open access · goldAbstract readClinical Trial, Phase I
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Takahiro NiikuraDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan. tniikura@med.kobe-u.ac.jp.ORCID http://orcid.org/0000-0003-0951-5812
Takashi IwakuraDepartment of Orthopaedic Surgery, Hyogo Prefectural Awaji Medical Center, Sumoto, Japan.
Takashi OmoriDivision of Biostatistics, Department of Social/Community Medicine and Health Science, Kobe University School of Medicine, Kobe, Japan.
Sang Yang LeeDepartment of Orthopaedic Surgery, Showa University School of Medicine, Tokyo, Japan.
Yoshitada SakaiDivision of Rehabilitation Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Toshihiro AkisueDepartment of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe, Japan.
Keisuke OeDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Tomoaki FukuiDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Takehiko MatsushitaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Tomoyuki MatsumotoDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Ryosuke KurodaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Kobe University · JPHyogo Prefectural Awaji Medical Center · JPShowa University · JP

Funding

ZENKYOREN (National Mutual Insurance Federation of Agricultural Cooperatives, Japan) Not applicable
6 · The paper itself

Abstract

backgroundClinicians have very limited options to improve fracture repair. Therefore, it is critical to develop a new clinically available therapeutic option to assist fracture repair biologically. We previously reported that the topical cutaneous application of carbon dioxide (CO

methodsPatients with fractures of the femur and tibia were prospectively enrolled into this study with ethical approval and informed consent. The CO

resultsNineteen patients were subjected to complete analysis. No adverse events were observed. Arterial and expired gas analyses revealed no adverse systemic effects including hypercapnia. The mean ratio of blood flow 20 min after CO

conclusionsThe findings of the present study revealed that CO

trial registrationThis study has been registered in the UMIN Clinical Trials Registry (Registration number: UMIN000013641, Date of registration: July 1, 2014).

Indexed as

Administration, TopicalAdultAgedBlood Flow VelocityCarbon DioxideFemaleFemoral Neck FracturesFollow-Up StudiesHumansHydrogelsMaleMiddle AgedProspective StudiesTibial FracturesTreatment OutcomeYoung AdultCarbon DioxideHydrogelsBlood flowBoneCarbon dioxideClinical trialFracture repair

Identifiers

PMID31766994
PMCPMC6878668
OpenAlexW2990617229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.