ArticleInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences2020
One and done? The effect of number of Pipeline embolization devices on aneurysm treatment outcomes.
Article in Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Efficacy and safety profiles of single versus multiple pipeline embolization devices for intracranial aneurysms: a systematic review and meta-analysis.Neurosurgical review · 2026Pooled it
- Flow Diversion of Posterior Circulation Aneurysms: Systematic Review of Disaggregated Individual Patient Data.AJNR. American journal of neuroradiology · 2021Pooled it
- Retreatment of previously flow diverted intracranial aneurysms with the pipeline embolization device.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2023Article
- Fluid dynamics in intracranial aneurysms treated with flow-diverting stents: effect of multiple geometrical parameters.Journal of fluid mechanics · 2023Article
- Impact of Endoluminal Flow Diverter Number on Aneurysm Treatment Outcomes: A Multicenter Study.Stroke (Hoboken, N.J.) · 2022Article
- Pipeline Embolization Device for the Treatment of Ruptured Intracerebral Aneurysms: A Multicenter Retrospective Study.Frontiers in neurology · 2021Article
- A novel score for evaluating cerebral aneurysms treated with flow diversion: 4F-flow diversion predictive score.Therapeutic advances in neurological disorders · 2021Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundControversy exists regarding the optimum number of flow diverters for the treatment of intracranial aneurysms. We explored the effect of the number of Pipeline embolization devices (PEDs; Medtronic, Dublin, Ireland) deployed on rates of aneurysm occlusion and complications.
methodsConsecutive patients who underwent saccular intracranial aneurysm treatment solely with the PED were included in this retrospective study. Computed tomographic, magnetic resonance, or digital subtraction angiographic images at 6 and 12 months and last follow-up (>12 months) were reviewed for aneurysm occlusion. Complication and retreatment rates were recorded and analyzed statistically.
resultsThe study included 141 aneurysm treatments in 119 patients. A single PED was deployed in 105 cases, two PEDs in 31 cases, and three PEDs in 5 cases (total = 182 devices). Six-month angiographic data were available for 103 patients. Occlusion rates were 67.1% for single-PED cases and 90.0% for cases with > 1 PED (p = 0.028). The 12-month occlusion rate (follow-up available for 132) for single-PED cases was 74.7% compared to 91.7% for multiple-PED cases (p = 0.04). On multivariate analysis, number of PEDs was an independent predictor of aneurysm occlusion at 12 months (odds ratio 6.3, 95% confidence interval 1.8-22.8, p = 0.005). Thromboembolic complication rates were the same in the single- and multiple-PED treatment groups (2.8%). The retreatment rate was higher in patients treated with a single PED (16.2% vs. 0%, p = 0.01).
conclusionsDeployment of > 1 Pipeline embolization device was associated with higher intracranial aneurysm occlusion and lower retreatment rates. No significant difference was found in complication rates.
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