Evidence map›Paper›PMID 31766759›Full record

ArticlePolymers2019

Development of Nontoxic Biodegradable Polyurethanes Based on Polyhydroxyalkanoate and L-lysine Diisocyanate with Improved Mechanical Properties as New Elastomers Scaffolds.

Cai Wang, Jiapeng Xie, Xuan Xiao, Shaojun Chen, Yiping Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cai WangGuangdong Research Center for Interfacial Engineering of Functional Materials, Shenzhen Key Laboratory of Polymer Science and Technology, Shenzhen Key Laboratory of Special Functional Materials, Nanshan District Key Lab for Biopolymers and Safety Evaluation, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.
Jiapeng XieGuangdong Research Center for Interfacial Engineering of Functional Materials, Shenzhen Key Laboratory of Polymer Science and Technology, Shenzhen Key Laboratory of Special Functional Materials, Nanshan District Key Lab for Biopolymers and Safety Evaluation, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.ORCID 0000-0002-5401-346X
Xuan XiaoGuangdong Research Center for Interfacial Engineering of Functional Materials, Shenzhen Key Laboratory of Polymer Science and Technology, Shenzhen Key Laboratory of Special Functional Materials, Nanshan District Key Lab for Biopolymers and Safety Evaluation, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.
Shaojun ChenGuangdong Research Center for Interfacial Engineering of Functional Materials, Shenzhen Key Laboratory of Polymer Science and Technology, Shenzhen Key Laboratory of Special Functional Materials, Nanshan District Key Lab for Biopolymers and Safety Evaluation, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.ORCID 0000-0001-8892-5136
Yiping WangKey Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A nontoxic and biodegradable polyurethane was prepared, characterized, and evaluated for biomedical applications. Stretchable, biodegradable, and biocompatible polyurethanes (LPH) based on L-lysine diisocyanate (LDI) with poly(ethylene glycol) (PEG) and polyhydroxyalkanoates(PHA) of different molar ratios were synthesized. The chemical and physical characteristics of the LPH films are tunable, enabling the design of mechanically performance, hydrophilic, and biodegradable behavior. The LPH films have a Young's modulus, tensile strength, and elongation at break in the range of 3.07-25.61 MPa, 1.01-9.49 MPa, and 102-998%, respectively. The LPH films demonstrate different responses to a change of temperature from 4 to 37 °C, with the swelling ratio for the same sample at equilibrium varying from 184% to 151%. In vitro degradation tests show the same LPH film has completely different degradation morphologies in pH of 3, 7.4, and 11 phosphate buffered solution (PBS). In vitro cell tests show feasibility that some of the LPH films are suitable for culturing rat bone marrow stem cells (rBMSCs), for future soft-tissue regeneration. The results demonstrate the feasibility of the LPH scaffolds for many biomedical applications.

Indexed as

biodegradableL-lysine diisocyanatemechanical performancenon-toxicpolyurethanes

Identifiers

PMID31766759
PMCPMC6960902

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.