ReviewInternational journal of molecular sciences2019
New Viral Facets in Oral Diseases: The EBV Paradox.
Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Pooled it
- Serological Evidence for the Association Between Epstein-Barr Virus Infection and Sjögren's Syndrome.Frontiers in immunology · 2020Pooled it
- Oral virome in health and disease.Journal of the American Dental Association (1939) · 2026Review
- Epstein-Barr Virus Infection Is Associated with an Elevated Tumor-Stroma Ratio and Older Age in Oral Squamous Cell Carcinoma.Viruses · 2026Article
- Cloning of a novel cyanobacterial serotonin N-acetyltransferase gene CySNAT3 and its integration with transcriptomic drug repurposing in pediatric obstructive sleep-disordered breathing.Frontiers in pharmacology · 2026Article
- Natural and induced immune responses in oral cavity and saliva.BMC immunology · 2025Review
- Molecular Detection of HPV, EBV, HSV-1, HCMV, andPathogens (Basel, Switzerland) · 2024Article
- Detection of Epstein-Barr virus infection in primary junctional epithelial cell cultures.Journal of oral microbiology · 2024Article
- Comparison of Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus viral load in peripheral blood mononuclear cells and oral fluids of HIV-negative individuals aged 3-89 years from Uganda.Infectious agents and cancer · 2023Article
- Epstein-Barr Virus History and Pathogenesis.Viruses · 2023Review
- Article
- Malignancy and viral infections in Sub-Saharan Africa: A review.Frontiers in virology (Lausanne, Switzerland) · 2023Article
- Epstein-Barr Virus in Salivary Samples from Systemic Lupus Erythematosus Patients with Oral Lesions.Journal of clinical medicine · 2021Article
- Review
- Clinical Implications of Polymicrobial Synergism Effects on Antimicrobial Susceptibility.Pathogens (Basel, Switzerland) · 2021Review
- Influence of Gestational Hormones on the Bacteria-Induced Cytokine Response in Periodontitis.Mediators of inflammation · 2021Review
- The oralome and its dysbiosis: New insights into oral microbiome-host interactions.Computational and structural biotechnology journal · 2021Review
- The Role of Bacterial and Fungal Human Respiratory Microbiota in COVID-19 Patients.BioMed research international · 2021Review
- Detection of Epstein-Barr Virus in Periodontitis: A Review of Methodological Approaches.Microorganisms · 2020Review
- Epstein-Barr Virus-Oral Bacterial Link in the Development of Oral Squamous Cell Carcinoma.Pathogens (Basel, Switzerland) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The oral cavity contributes to overall health, psychosocial well-being and quality of human life. Oral inflammatory diseases represent a major global health problem with significant social and economic impact. The development of effective therapies, therefore, requires deeper insights into the etiopathogenesis of oral diseases. Epstein-Barr virus (EBV) infection results in a life-long persistence of the virus in the host and has been associated with numerous oral inflammatory diseases including oral lichen planus (OLP), periodontal disease and Sjogren's syndrome (SS). There is considerable evidence that the EBV infection is a strong risk factor for the development and progression of these conditions, but is EBV a true pathogen? This long-standing EBV paradox yet needs to be solved. This review discusses novel viral aspects of the etiopathogenesis of non-tumorigenic diseases in the oral cavity, in particular, the contribution of EBV in OLP, periodontitis and SS, the tropism of EBV infection, the major players involved in the etiopathogenic mechanisms and emerging contribution of EBV-pathogenic bacteria bidirectional interaction. It also proposes the involvement of EBV-infected plasma cells in the development and progression of oral inflammatory diseases. A new direction for preventing and treating these conditions may focus on controlling pathogenic EBV with anti-herpetic drugs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.